{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:42:49Z","timestamp":1773931369382,"version":"3.50.1"},"reference-count":60,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"name":"Marie-Sklodowska Curie Action Innovative Training Network","award":["721281"],"award-info":[{"award-number":["721281"]}]},{"DOI":"10.13039\/100007333","name":"Alzheimer&#x0027;s Disease Neuroimaging Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007333","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG024904"],"award-info":[{"award-number":["U01 AG024904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer&#x0027;s Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002565","name":"Alzheimer&#x0027;s Drug Discovery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Elan Pharmaceuticals, Inc."},{"DOI":"10.13039\/100015324","name":"Janssen Alzheimer Immunotherapy Research And Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014489","name":"Johnson and Johnson Pharmaceutical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014489","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007054","name":"Meso Scale Diagnostics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NeuroRx Research; Neurotrack Technologies"},{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE J. Biomed. Health Inform."],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1109\/jbhi.2020.2984355","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T23:51:04Z","timestamp":1588031464000},"page":"218-226","source":"Crossref","is-referenced-by-count":104,"title":["Early Detection of Alzheimer's Disease with Blood Plasma Proteins Using Support Vector Machines"],"prefix":"10.1109","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3095-357X","authenticated-orcid":false,"given":"Chima S.","family":"Eke","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3826-3212","authenticated-orcid":false,"given":"Emmanuel","family":"Jammeh","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6411-4045","authenticated-orcid":false,"given":"Xinzhong","family":"Li","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7472-953X","authenticated-orcid":false,"given":"Camille","family":"Carroll","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6935-8698","authenticated-orcid":false,"given":"Stephen","family":"Pearson","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8362-6292","authenticated-orcid":false,"given":"Emmanuel","family":"Ifeachor","sequence":"additional","affiliation":[]}],"member":"263","reference":[{"key":"ref39","first-page":"41","article-title":"Applications of support vector machine (SVM) learning in cancer genomics","volume":"15","author":"huang","year":"2018","journal-title":"Cancer Genomics-Proteomics"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1109\/78.650102"},{"key":"ref33","first-page":"1022","article-title":"Multi-interval discretization of continuous-valued attributes for classification learning","author":"fayyad","year":"1993","journal-title":"Proc Int Joint Conf Artif Intell"},{"key":"ref32","author":"ghiselli","year":"1964","journal-title":"Theory of Psychological Measurement"},{"key":"ref31","first-page":"235","article-title":"Feature selection for machine learning: comparing a correlation-based filter approach to the wrapper","author":"hall","year":"1999","journal-title":"Proc FLAIRS Conf"},{"key":"ref30","article-title":"Correlation-based feature selection for machine learning","author":"hall","year":"1999"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/BF00994018"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1002\/j.1538-7305.1948.tb01338.x"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/BF00116251"},{"key":"ref34","first-page":"3","volume":"1","author":"press","year":"1988","journal-title":"Numerical Recipes in C"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2016.03.002"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mkn041"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2019.11.001"},{"key":"ref29","first-page":"1137","article-title":"A study of cross-validation and bootstrap for accuracy estimation and model selection","author":"kohavi","year":"1995","journal-title":"Proc Int Joint Conf Artif Intell"},{"key":"ref2","author":"prince","year":"2016","journal-title":"World Alzheimer report 2016 improving healthcare for people living with dementia coverage quality and costs now and in the future"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.001"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028092"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31826d597a"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31827b60d2"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC.2018.8513293"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC.2016.7591217"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1373\/jalm.2019.029595"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.03.007"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212261"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2016.1193861"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbx130"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35789-3"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2018.1460016"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-019-0122-0"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13395-9"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucom.2019.10.091"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1040752"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-015-0233-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00025"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2017.04.005"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-6080(99)00032-5"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-05719-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05066.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2012.1070"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0006-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl279"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/nm1653"},{"key":"ref18","article-title":"Identification of a 5-protein biomarker molecular signature for predicting Alzheimer's disease","volume":"3","author":"ravetti","year":"2008","journal-title":"PLoS ONE"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000330750"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.02.002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14079"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1918-8"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.09.84"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180412"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf074"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1109\/TSMCA.2009.2029559"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.206"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2011.63"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0197-4580(98)00022-0","article-title":"Consensus report of the working group on:&#x2018;Molecular and biochemical markers of Alzheimer's disease","volume":"19","author":"davies","year":"1998","journal-title":"Neurobiology of Aging"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1145\/1656274.1656278"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1109\/ICMLA.2007.76"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1007\/s40120-017-0069-5"}],"container-title":["IEEE Journal of Biomedical and Health Informatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/6221020\/9313839\/09078785.pdf?arnumber=9078785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T11:23:34Z","timestamp":1666437814000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/9078785\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":60,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1109\/jbhi.2020.2984355","relation":{},"ISSN":["2168-2194","2168-2208"],"issn-type":[{"value":"2168-2194","type":"print"},{"value":"2168-2208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}