{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T08:42:15Z","timestamp":1782376935766,"version":"3.54.5"},"reference-count":48,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61832019"],"award-info":[{"award-number":["61832019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Provincial Science and Technology Program","award":["2019CB1007"],"award-info":[{"award-number":["2019CB1007"]}]},{"name":"Hunan Provincial Science and Technology Program","award":["2021RC0048"],"award-info":[{"award-number":["2021RC0048"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE J. Biomed. Health Inform."],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1109\/jbhi.2023.3315073","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:39:47Z","timestamp":1694626787000},"page":"6112-6120","source":"Crossref","is-referenced-by-count":27,"title":["Fusion-Based Deep Learning Architecture for Detecting Drug-Target Binding Affinity Using Target and Drug Sequence and Structure"],"prefix":"10.1109","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1664-5943","authenticated-orcid":false,"given":"Kaili","family":"Wang","sequence":"first","affiliation":[{"name":"Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0188-1394","authenticated-orcid":false,"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Lab on Bioinformatics, School of Computer Science and Engineering, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa858"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1021\/ci500081m"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz111"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.7b00616"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab072"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbu010"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa921"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/92.4.965"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/nature14539"},{"key":"ref30","first-page":"807","article-title":"Rectified linear units improve restricted boltzmann machines","author":"nair","year":"0","journal-title":"Proc 27th Int Conf Mach Learn"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"821i","DOI":"10.1093\/bioinformatics\/bty593","article-title":"DeepDTA: Deep drug–target binding affinity prediction","volume":"34","author":"\u00f6zt\u00fcrk","year":"2018","journal-title":"Bioinformatics"},{"key":"ref33","first-page":"1929","article-title":"Dropout: A simple way to prevent neural networks from overfitting","volume":"15","author":"srivastava","year":"2014","journal-title":"J Mach Learn Res"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-017-0088-4"},{"key":"ref32","article-title":"Graph warp module: An auxiliary module for boosting the power of graph neural networks in molecular graph analysis","author":"ishiguro","year":"2019"},{"key":"ref2","first-page":"308","article-title":"FingerDTA: A fingerprint-embedding framework for drug-target binding affinity prediction","volume":"6","author":"zhu","year":"2022","journal-title":"Big data mining and analytics"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab117"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty374"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1038\/nature09589"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad340"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2013.07.014"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.0c01306"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-021-04466-0"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/minf.201800082"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.148155"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1021\/ci400709d"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-020-02345-9"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.01.025"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082138"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07476.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1021\/jm030580l"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01059-7"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1038"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700203"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.8b00545"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2108728118"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/bip.360221211"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1818"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.9b00438"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1021\/ci300604z"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016357811882"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.08.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab476"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00689-x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-016-0791-z"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2020.105495"}],"container-title":["IEEE Journal of Biomedical and Health Informatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/6221020\/10345388\/10250911.pdf?arnumber=10250911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T23:00:03Z","timestamp":1702422003000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/10250911\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":48,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.1109\/jbhi.2023.3315073","relation":{},"ISSN":["2168-2194","2168-2208"],"issn-type":[{"value":"2168-2194","type":"print"},{"value":"2168-2208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]}}}