{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:54:42Z","timestamp":1776228882126,"version":"3.50.1"},"reference-count":58,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"name":"National Key R&D Program of China","award":["2023YFC2506400"],"award-info":[{"award-number":["2023YFC2506400"]}]},{"name":"National Key R&D Program of China","award":["2024YFA1306900"],"award-info":[{"award-number":["2024YFA1306900"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62172274"],"award-info":[{"award-number":["62172274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020717","name":"Center for High Performance Computing, Shanghai Jiao Tong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE J. Biomed. Health Inform."],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1109\/jbhi.2024.3514089","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T13:33:49Z","timestamp":1739194429000},"page":"2271-2283","source":"Crossref","is-referenced-by-count":11,"title":["GRATCR: Epitope-Specific T Cell Receptor Sequence Generation With Data-Efficient Pre-Trained Models"],"prefix":"10.1109","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5431-2307","authenticated-orcid":false,"given":"Zhenghong","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3614-1553","authenticated-orcid":false,"given":"Junwei","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4925-7402","authenticated-orcid":false,"given":"Shenggeng","family":"Lin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"}]},{"given":"Liang","family":"Hong","sequence":"additional","affiliation":[{"name":"Artificial Intelligence Biomedical Center, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4200-7502","authenticated-orcid":false,"given":"Dong-Qing","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-6725","authenticated-orcid":false,"given":"Yi","family":"Xiong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/boc.201900093"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.05.013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-09789-3_1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032414-112334"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/ni1502"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00185-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ni1173"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0007-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.522110"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf3700"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.215840"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-024-00504-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.07.017"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.7150\/jca.18681"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.835762"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3565"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12141"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.794183"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-023-00534-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-01072-6"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2022.09.007"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s43588-023-00555-7"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa318"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad086"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-021-00383-2"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01803"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4841"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab294"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1014256"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0291"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-29119-7_11"},{"key":"ref32","article-title":"De novo generation of T-cell receptors with desired epitope-binding property by leveraging a pre-trained large language model","author":"Yang","year":"2023"},{"key":"ref33","doi-asserted-by":"crossref","DOI":"10.1101\/2023.09.12.557285","article-title":"TAPIR: A T-cell receptor language model for predicting rare and novel targets","author":"Fast","year":"2023"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/334395a0"},{"key":"ref35","first-page":"2735","article-title":"Multilingual translation via grafting pre-trained language models","author":"Sun","year":"2021"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1006"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa796"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.21417\/adpt2020covid"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz614"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01578-0"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx286"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1810.04805"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbac409"},{"key":"ref44","article-title":"Diverse beam search: Decoding diverse solutions from neural sequence models","author":"Vijayakumar","year":"2016"},{"key":"ref45","article-title":"TCR2vec: A deep representation learning framework of T-cell receptor sequence and function","author":"Yuepeng","year":"2023"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.893247"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-023-00634-4"},{"key":"ref49","doi-asserted-by":"crossref","DOI":"10.1101\/433706","article-title":"NetTCR: Sequence-based prediction of TCR binding to peptide-MHC complexes using convolutional neural networks","author":"Jurtz","year":"2018"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008814"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02820"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-023-00727-0"},{"key":"ref53","doi-asserted-by":"crossref","DOI":"10.1101\/2024.03.26.586756","article-title":"Baselining the buzz trastuzumab-HER2 affinity, and beyond","author":"Chinery","year":"2024"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/31450"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-023-00835-3"},{"issue":"1","key":"ref56","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0022-2836(84)90231-6","article-title":"Solvent accessible surface area and excluded volume in proteins. Analytical equations for overlapping spheres and implications for the hydrophobic effect","volume":"178","author":"Richmond","year":"1984","journal-title":"J. Mol. Biol."},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-019-02401-0"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.12.010"}],"container-title":["IEEE Journal of Biomedical and Health Informatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/6221020\/10916525\/10878495.pdf?arnumber=10878495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:46:09Z","timestamp":1741355169000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/10878495\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":58,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1109\/jbhi.2024.3514089","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.07.21.604503","asserted-by":"object"}]},"ISSN":["2168-2194","2168-2208"],"issn-type":[{"value":"2168-2194","type":"print"},{"value":"2168-2208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}