{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:40:14Z","timestamp":1775522414945,"version":"3.50.1"},"reference-count":63,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"name":"Ministry of Education, Taiwan"},{"name":"Pandemic Sciences Institute at the University of Oxford"},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Oxford Biomedical Research Centre"},{"name":"NIHR Research Professorship"},{"DOI":"10.13039\/501100000287","name":"Royal Academy of Engineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000287","id-type":"DOI","asserted-by":"publisher"}]},{"name":"InnoHK Hong Kong Centre for Centre for Cerebro-cardiovascular Engineering"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE J. Biomed. Health Inform."],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1109\/jbhi.2025.3541004","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T18:22:42Z","timestamp":1739384562000},"page":"5291-5302","source":"Crossref","is-referenced-by-count":1,"title":["AI-Assisted in Silico Trial for the Optimization of Osmotherapy After Ischaemic Stroke"],"prefix":"10.1109","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4302-5710","authenticated-orcid":false,"given":"Xi","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9139-8955","authenticated-orcid":false,"given":"Lei","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5082-0299","authenticated-orcid":false,"given":"Tam\u00e1s I.","family":"J\u00f3zsa","sequence":"additional","affiliation":[{"name":"School of Aerospace, Transport and Manufacturing Cranfield University, Cranfield, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiandong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9848-8555","authenticated-orcid":false,"given":"David A.","family":"Clifton","sequence":"additional","affiliation":[{"name":"Oxford Suzhou Centre for Advanced Research, University of Oxford, Suzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1156-2810","authenticated-orcid":false,"given":"Stephen J.","family":"Payne","sequence":"additional","affiliation":[{"name":"Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106029"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-020-00959-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.922181"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fstro.2023.1119120"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/11101849.2022.2077052"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2022.03.056"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxac368"},{"key":"ref8","first-page":"293","article-title":"Osmotherapy","volume-title":"Springer Ebooks","author":"Klsen-Petersen","year":"2020"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-07129-z"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04311-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000001432"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-1963-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-018-0991-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.558125"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.104802"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-55594-8_15"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2023.111803"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1098\/rsfs.2019.0127"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-021-02808-w"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1088\/2516-1091\/accc62"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/ehjdh\/ztae014"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1109\/ssci44817.2019.9002703"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.2024.3378843"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-023-03354-3"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cma.2022.114913"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2022.106226"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.apm.2023.04.031"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.50.6.1699"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093\/jom\/ufad040"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1161\/hs0102.100877"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s11831-019-09352-w"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1109\/tbme.2020.3024117"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-019-01131-7"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14985"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2017-000087"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjae.2018.05.005"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-023-00952-2"},{"key":"ref38","article-title":"Predict, refine, synthesize: Self-guiding diffusion models for probabilistic time series forecasting","author":"Kollovieh","year":"2023"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1414792"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1177\/1747493017710341"},{"key":"ref41","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-23099-8","article-title":"Automated solution of differential equations by the finite element method: The FENICS Book","author":"Logg","year":"2012"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijengsci.2019.103204"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-020-00211-2"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0b013e31827ca4b3"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.977608"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.117889"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2009.02.089"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249384"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00031.2020"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4485-1"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28722"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.3_Part_1.500"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.58.12.1866"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1994.tb02647.x"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-013-9907-1"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200038010-00002"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.4.469"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-011-9649-x"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1097\/ta.0b013e3181acc726"},{"issue":"2","key":"ref60","first-page":"437","article-title":"Cerebral ischemia. II. The no-reflow phenomenon","volume":"52","author":"Ames","year":"1968","journal-title":"Amer. J. Pathol."},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2014-011491"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2022-019213"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.01.007"}],"container-title":["IEEE Journal of Biomedical and Health Informatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/6221020\/11068702\/10882905.pdf?arnumber=10882905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T17:51:52Z","timestamp":1751651512000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/10882905\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":63,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.1109\/jbhi.2025.3541004","relation":{},"ISSN":["2168-2194","2168-2208"],"issn-type":[{"value":"2168-2194","type":"print"},{"value":"2168-2208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}