{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:14:43Z","timestamp":1778184883729,"version":"3.51.4"},"reference-count":66,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62072070"],"award-info":[{"award-number":["62072070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["3132024265"],"award-info":[{"award-number":["3132024265"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE J. Biomed. Health Inform."],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1109\/jbhi.2025.3571801","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T13:16:04Z","timestamp":1747746964000},"page":"7704-7716","source":"Crossref","is-referenced-by-count":2,"title":["Sign-Aware Graph Contrastive Learning for Drug Repositioning"],"prefix":"10.1109","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8207-7690","authenticated-orcid":false,"given":"Hai","family":"Cui","sequence":"first","affiliation":[{"name":"Information Science and Technology College, Dalian Maritime University, Dalian, Liaoning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7171-2695","authenticated-orcid":false,"given":"Meiyu","family":"Duan","sequence":"additional","affiliation":[{"name":"Information Science and Technology College, Dalian Maritime University, Dalian, Liaoning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Information Science and Technology College, Dalian Maritime University, Dalian, Liaoning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwei","family":"Ma","sequence":"additional","affiliation":[{"name":"Information Science and Technology College, Dalian Maritime University, Dalian, Liaoning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5843-4675","authenticated-orcid":false,"given":"Yijia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Information Science and Technology College, Dalian Maritime University, Dalian, Liaoning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03233-x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2024.3434439"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbae650"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1109\/TNNLS.2022.3175772"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ipm.2023.103403"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1145\/3626772.3657747"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2023.3254163"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.24963\/ijcai.2023\/537"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-023-00640-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1145\/3459637.3482392"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1145\/3459637.3482478"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/00223980.1946.9917275"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1145\/3539618.3591655"},{"key":"ref14","article-title":"Clustering signed networks with the geometric mean of Laplacians","volume-title":"Proc. Adv. Neural Inf. Process. Syst. (NeuIPS)","volume":"29","author":"Mercado","year":"2016"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad357"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2023.121855"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2024.3351079"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2023.3335275"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.knosys.2024.112222"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.knosys.2023.111329"},{"key":"ref21","article-title":"A generalization of transformer networks to graphs","author":"Dwivedi","year":"2020"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1145\/3366423.3380027"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1609\/aaai.v37i4.25565"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.48550\/ARXIV.1706.03762"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1145\/3539618.3591734"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1145\/3543507.3583412"},{"key":"ref27","article-title":"Embedding entities and relations for learning and inference in knowledge bases","volume-title":"Proc. 3rd Int. Conf. Learn. Representations","author":"Yang","year":"2015"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.4324\/9780203786031-11"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-018-2220-4"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw228"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.26"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab515"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-022-05069-z"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2023.10.014"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbac384"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab581"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2023.3344031"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2024.3372527"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-023-01960-3"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.898679"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200825030-00002"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00164"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2016.05.003"},{"issue":"6","key":"ref44","first-page":"761","article-title":"Effect of topiramate on apoptosis-related protein expression of hippocampus in model rats with Alzheimers disease","volume":"18","author":"Cheng","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00562"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.15020248"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1159\/000529915"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0397-4"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-024-06087-9"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1109\/BIBM58861.2023.10386002"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2022.3194891"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1109\/TCBB.2023.3292883"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2024.102805"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1109\/TETC.2023.3239949"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ins.2024.121360"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2021.116165"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad748"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.knosys.2023.111187"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.inffus.2024.102563"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad516"},{"key":"ref61","article-title":"Revisiting graph neural networks: All we have is low-pass filters","author":"Nt","year":"2019"},{"key":"ref62","article-title":"Is homophily a necessity for graph neural networks?","volume-title":"Proc. 10th Int. Conf. Learn. Representations","author":"Ma","year":"2022"},{"key":"ref63","article-title":"PANE-GNN: Unifying Positive and Negative Edges in Graph Neural Networks for Recommendation","author":"Liu","year":"2023"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1109\/ICDM.2018.00113"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1145\/3539618.3591765"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1109\/TNSE.2024.3524077"}],"container-title":["IEEE Journal of Biomedical and Health Informatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/6221020\/11192794\/11007245.pdf?arnumber=11007245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T18:34:30Z","timestamp":1765305270000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11007245\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":66,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.1109\/jbhi.2025.3571801","relation":{},"ISSN":["2168-2194","2168-2208"],"issn-type":[{"value":"2168-2194","type":"print"},{"value":"2168-2208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]}}}