{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:12:37Z","timestamp":1760015557912},"reference-count":40,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Des. Test. Comput."],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1109\/mdt.2012.2193370","type":"journal-article","created":{"date-parts":[[2012,4,12]],"date-time":"2012-04-12T21:02:29Z","timestamp":1334264549000},"page":"7-20","source":"Crossref","is-referenced-by-count":16,"title":["Design Automation for Synthetic Biological Systems"],"prefix":"10.1109","volume":"29","author":[{"given":"Douglas","family":"Densmore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soha","family":"Hassoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref39","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/35002131","article-title":"Construction of a genetic toggle switch in Escherichia coli","volume":"403","author":"gardner","year":"2000","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073374"},{"key":"ref33","author":"terzer","year":"2009","journal-title":"Lrge Scale Methods to Enumerate Extreme Rays and Elementary Modes"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1142\/S0218339094000131"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1023"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1042\/bj2380781"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2011.01.006"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2872004"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq318"},{"key":"ref34","first-page":"144","article-title":"An algorithm for identifying dominant-edge metabolic pathways","author":"ullah","year":"0","journal-title":"Proc IEEE\/ACM Int Conf Comput -Aided Design (ICCAD) Dig Tech Papers"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1318"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1038\/35002125"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022490"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018882"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2008.0516.focus"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.2010.2069631"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1109\/CDC.2008.4739253"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq165"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1109\/TNB.2009.2028687"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1413"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/1754-1611-3-19"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2011.04.001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/nature06450"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/nature08721"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.378"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nature08187"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"8264","DOI":"10.1021\/bi201284u","article-title":"The original Michaelis constant: Translation of the 1913 Michaelis-Menten paper","volume":"50","author":"michaelis","year":"2011","journal-title":"Biochemistry"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000219381"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nature09565"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511790515"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.10.076"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/1754-1611-4-1"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04640"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385120-8.00006-1"},{"key":"ref22","article-title":"Developer's and user's guide to clotho v2.0 a software platform for the creation of synthetic biological systems","volume":"498","author":"xia","year":"0","journal-title":"Methods Enzymol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp361"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1021\/sb2000116"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp457"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02708-07"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp029"}],"container-title":["IEEE Design & Test of Computers"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx5\/54\/6327704\/06178303.pdf?arnumber=6178303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,11,14]],"date-time":"2017-11-14T00:51:57Z","timestamp":1510620717000},"score":1,"resource":{"primary":{"URL":"http:\/\/ieeexplore.ieee.org\/document\/6178303\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6]]},"references-count":40,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1109\/mdt.2012.2193370","relation":{},"ISSN":["0740-7475"],"issn-type":[{"value":"0740-7475","type":"print"}],"subject":[],"published":{"date-parts":[[2012,6]]}}}