{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:32:42Z","timestamp":1766748762149,"version":"3.40.5"},"reference-count":48,"publisher":"IEEE","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1109\/smc.2014.6974294","type":"proceedings-article","created":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T22:27:18Z","timestamp":1418077638000},"page":"2452-2457","source":"Crossref","is-referenced-by-count":14,"title":["Drug delivery system for general anesthesia: Where are we?"],"prefix":"10.1109","author":[{"given":"Dana","family":"Copot","sequence":"first","affiliation":[]},{"given":"Clara M.","family":"Ionescu","sequence":"additional","affiliation":[]}],"member":"263","reference":[{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-01411-1_8"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-010-9170-4"},{"key":"ref33","first-page":"100","article-title":"Fractional calculus in bioengineering","volume":"32","author":"magin","year":"2004","journal-title":"Critical Reviews in Biomedical Engineering"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016031129053"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/BF00543506"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/BF01065658"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-010-9153-5"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-009-9116-x"},{"key":"ref35","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4471-5388-7","article-title":"The human respiratory system: an analysis of the interplay between anatomy, structure, breathing and fractal dynamics","author":"ionescu","year":"2013"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnsns.2010.05.027"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318205680b"},{"key":"ref40","first-page":"150","article-title":"Drug diffusion through cell membrane as a step towards modeling pain relief during anesthesia","author":"copot","year":"2013","journal-title":"International conference on mathematical methods in engi-neering&#x2019; 2226"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/acs.1087","article-title":"Robust control of depth of anaesthesia","volume":"23","author":"dumont","year":"2009","journal-title":"International Journal of Adaptive Control Signal Processing"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1049\/ip-d.1990.0032"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-005-2222-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2000.01527.x"},{"article-title":"Compartmental analysis in biology and medicine","year":"1985","author":"jacques","key":"ref15"},{"journal-title":"Biochemistry","year":"2002","author":"berg","key":"ref16"},{"key":"ref17","first-page":"5273","article-title":"Pharmacokinetic and pharmacodynamic modeling in vivo","author":"holford","year":"1981","journal-title":"Critical Reviews in Bioengineering"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2005.09.002"},{"key":"ref19","first-page":"620","volume":"96","author":"takamatsu","year":"2006","journal-title":"Entropy indices vs the bis-pectral index for estimating nociception during sevoflurane anaesthesia British Journal Anaesthesiology"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200012000-00049"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1109\/TCST.2011.2162412"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199701000-00005"},{"key":"ref3","first-page":"89e","volume":"114","author":"nogueira","year":"2014","journal-title":"Controlling the depth of anesthesia by a novel positive control strategy Computer methods and programs in biomedicine"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2014.01.002"},{"article-title":"Modeling in Biopharmaceutics, Pharma-cokinetics, and Phamacodynamics: Homogeneous and Heterogeneous Approaches","year":"2006","author":"macheas","key":"ref29"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177\/193229681300700316"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200310000-00010"},{"key":"ref7","first-page":"26","volume":"103","author":"absalom","year":"2009","journal-title":"Pharmacokinetic models for propofoldefining and illuminating the devil in the detail British Journal of Anaesthesiology"},{"key":"ref2","volume":"28","author":"dumont","year":"2014","journal-title":"Feedback control for clinicians Journal of Clinical Monitoring and Computing"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1109\/MCS.2005.1411383"},{"key":"ref1","first-page":"516","volume":"112","author":"absalom","year":"2011","journal-title":"Closed loop anaesthesia are we getting close to finding the Holy Grail? Anesthesia and Analgesia"},{"key":"ref46","article-title":"Predictive Adaptive Control of the Bispectral Index of the EEG (BIS): Exploring Electromyography as an Accesible Disturbance","author":"nunes","year":"2007","journal-title":"Proceedings of the 15th Mediterranean Conference on Control and Automation Athena"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199710000-00019"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1109\/ACC.2003.1239858"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200403000-00026"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2008.923142"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2008.923142"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.1999.430903.x"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.44.101802.121453"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199401000-00018"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-010-9150-8"},{"key":"ref23","first-page":"41","volume":"67","author":"marsh","year":"1991","journal-title":"Pharmacokinetic model driven infusion of propofol in children British Journal of Anaesthesia"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-005-9002-0"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199906000-00003"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200006000-00017"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199805000-00006"}],"event":{"name":"2014 IEEE International Conference on Systems, Man and Cybernetics - SMC","start":{"date-parts":[[2014,10,5]]},"location":"San Diego, CA, USA","end":{"date-parts":[[2014,10,8]]}},"container-title":["2014 IEEE International Conference on Systems, Man, and Cybernetics (SMC)"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/6960119\/6973862\/06974294.pdf?arnumber=6974294","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T23:52:49Z","timestamp":1747180369000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/6974294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":48,"URL":"https:\/\/doi.org\/10.1109\/smc.2014.6974294","relation":{},"subject":[],"published":{"date-parts":[[2014,10]]}}}