{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:21:28Z","timestamp":1778692888155,"version":"3.51.4"},"reference-count":38,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"DOI":"10.13039\/501100019217","name":"Institut de Valorisation des Donn\u00e9es","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019217","id-type":"DOI","asserted-by":"publisher"}]},{"name":"New Frontier Research - Rapid Response Fund"},{"name":"IUCPQ Biobank and Foundation"},{"name":"SynergiQC Project\/CQDM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Trans. Biomed. Eng."],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1109\/tbme.2025.3599011","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T18:46:52Z","timestamp":1755197212000},"page":"1134-1145","source":"Crossref","is-referenced-by-count":7,"title":["Lung-DDPM: Semantic Layout-Guided Diffusion Models for Thoracic CT Image Synthesis"],"prefix":"10.1109","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7369-7123","authenticated-orcid":false,"given":"Yifan","family":"Jiang","sequence":"first","affiliation":[{"name":"Centre de recherche du CHU de Qu&#x00E9;bec-Universit&#x00E9; Laval, Qu&#x00E9;bec, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yannick","family":"Lemar\u00e9chal","sequence":"additional","affiliation":[{"name":"Centre de recherche de l&#x0027;Institut Universitaire de cardiologie et de pneumologie de Qu&#x00E9;bec-Universit&#x00E9; Laval, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Plante","sequence":"additional","affiliation":[{"name":"Centre de recherche de l&#x0027;Institut Universitaire de cardiologie et de pneumologie de Qu&#x00E9;bec-Universit&#x00E9; Laval, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9e","family":"Bafaro","sequence":"additional","affiliation":[{"name":"Centre de recherche de l&#x0027;Institut Universitaire de cardiologie et de pneumologie de Qu&#x00E9;bec-Universit&#x00E9; Laval, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Abi-Rjeile","sequence":"additional","affiliation":[{"name":"Centre de recherche de l&#x0027;Institut Universitaire de cardiologie et de pneumologie de Qu&#x00E9;bec-Universit&#x00E9; Laval, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4163-7353","authenticated-orcid":false,"given":"Philippe","family":"Joubert","sequence":"additional","affiliation":[{"name":"Centre de recherche de l&#x0027;Institut Universitaire de cardiologie et de pneumologie de Qu&#x00E9;bec-Universit&#x00E9; Laval, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Despr\u00e9s","sequence":"additional","affiliation":[{"name":"Centre de recherche de l&#x0027;Institut Universitaire de cardiologie et de pneumologie de Qu&#x00E9;bec-Universit&#x00E9; Laval, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1427-2819","authenticated-orcid":false,"given":"Venkata","family":"Manem","sequence":"additional","affiliation":[{"name":"Centre de recherche du CHU de Qu&#x00E9;bec-Universit&#x00E9; Laval, Qu&#x00E9;bec, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/onco4020008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2023.103061"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01345"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-16443-9_60"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14676"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMlim035027"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.118.005122"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2019.10.006"},{"key":"ref11","article-title":"How much data is needed to train a medical image deep learning system to achieve necessary high accuracy?","author":"Cho","year":"2015"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2024.3385504"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2020.3042523"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-43999-5_56"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2022.3172976"},{"key":"ref16","article-title":"Generative enhancement for 3D medical images","author":"Zhu","year":"2024"},{"key":"ref17","first-page":"6840","article-title":"Denoising diffusion probabilistic models","volume-title":"Proc. Adv. Neural Inf. Process. Syst.","volume":"33","author":"Ho","year":"2020"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44824-z"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-020-01008-z"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1088\/2057-1976\/acfb06"},{"key":"ref21","article-title":"Three-dimensional medical image synthesis with denoising diffusion probabilistic models","volume-title":"Proc. Med. Imag. With Deep Learn.","author":"Dorjsembe","year":"2022"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1118\/1.3528204"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1109\/CVPR.2018.00917"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2010.08.005"},{"key":"ref25","first-page":"6626","article-title":"GANs trained by a two time-scale update rule converge to a local Nash equilibrium","volume-title":"Proc. Adv. Neural Inf. Process. Syst.","author":"Heusel","year":"2017"},{"issue":"1","key":"ref26","first-page":"723","article-title":"A kernel two-sample test","volume":"13","author":"Gretton","year":"2012","journal-title":"J. Mach. Learn. Res."},{"key":"ref27","article-title":"Med3D: Transfer learning for 3 D medical image analysis","author":"Chen","year":"2019"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-020-00331-0"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/sym12111787"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2020.2971542"},{"key":"ref31","article-title":"Attention U-Net: Learning where to look for the pancreas","author":"Oktay","year":"2018"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucom.2018.09.013"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1007\/s10489-022-03609-x"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3389\/fradi.2024.1385742"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1145\/3596711.3596772"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.isprsjprs.2007.05.009"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2022.106391"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1186\/s40537-023-00727-2"}],"container-title":["IEEE Transactions on Biomedical Engineering"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/10\/11395415\/11124548.pdf?arnumber=11124548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:48:53Z","timestamp":1771015733000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11124548\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":38,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1109\/tbme.2025.3599011","relation":{},"ISSN":["0018-9294","1558-2531"],"issn-type":[{"value":"0018-9294","type":"print"},{"value":"1558-2531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]}}}