{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:47:40Z","timestamp":1778057260139,"version":"3.51.4"},"reference-count":89,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"2","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61772552"],"award-info":[{"award-number":["61772552"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61428209"],"award-info":[{"award-number":["61428209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE\/ACM Trans. Comput. Biol. and Bioinf."],"published-print":{"date-parts":[[2022,3,1]]},"DOI":"10.1109\/tcbb.2020.3019781","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T20:16:47Z","timestamp":1598473007000},"page":"953-965","source":"Crossref","is-referenced-by-count":13,"title":["Identifying Gene Signatures for Cancer Drug Repositioning Based on Sample Clustering"],"prefix":"10.1109","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2157-9931","authenticated-orcid":false,"given":"Fei","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulian","family":"Ding","sequence":"additional","affiliation":[{"name":"Division of Biomedical Engineering, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9901-1732","authenticated-orcid":false,"given":"Xiujuan","family":"Lei","sequence":"additional","affiliation":[{"name":"School of Computer Science, Shaanxi Normal University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3383-5691","authenticated-orcid":false,"given":"Bo","family":"Liao","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics, Hainan Normal University, Haikou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4593-9332","authenticated-orcid":false,"given":"Fang-Xiang","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics, Hainan Normal University, Haikou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-08-0333"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32200"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.3109\/01913123.2013.852645"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1021\/np400441f"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1500"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.11.013"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.12.058"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-7-519"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2012.12.002"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00375"},{"key":"ref78","first-page":"10","article-title":"Danazol treatment of advanced breast cancer","volume":"64","author":"coombes","year":"1980","journal-title":"Cancer Treat Rep"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-06-0003"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1109\/TST.2015.7297749"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1204"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/18.11.1454"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1155\/JBB.2005.96"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038\/35075138"},{"key":"ref35","first-page":"20","article-title":"Bridging centrality: Identifying bridging nodes in scale-free networks","author":"hwang","year":"2006","journal-title":"Proc 12th ACM SIGKDD Int Conf Knowl Discov Data Mining"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ins.2013.05.027"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0633-9"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009283431302"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.09.020"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.12.018"},{"key":"ref28","first-page":"281","article-title":"Some methods for classification and analysis of multivariate observations","volume":"1","author":"macqueen","year":"1967","journal-title":"Proc 5th Berkeley Symp Math Stat Probability"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1084"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031906"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-016-1494-0"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1021\/cb400759d"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti270"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1038\/sj.pcan.4500852"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2008.05.010"},{"key":"ref69","first-page":"1772","article-title":"Rapamycin inhibits prostate cancer cell growth through cyclin D1 and enhances the cytotoxic efficacy of cisplatin","volume":"6","author":"imrali","year":"2016","journal-title":"Amer J Cancer Res"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3078"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu403"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl467"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00298"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-015-0845-0"},{"key":"ref24","article-title":"A review of drug repositioning based chemical-induced cell line expression data","author":"wang","year":"0"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005633"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00193"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl476"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604010"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.068668"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.3.371"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.5.619"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.11.079"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.5313"},{"key":"ref55","first-page":"1957","article-title":"The in vitro and in vivo effects of 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), a specific inhibitor of phosphatidylinositol 3-kinase, in human colon cancer cells","volume":"8","author":"semba","year":"2002","journal-title":"Clin Cancer Res"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154605"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2009.0629"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i3.340"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2044"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2017.11.001"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1198\/jasa.2010.tm09329"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty325"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty133"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"991d","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: Archive for functional genomics data setsupdate","volume":"41","author":"barrett","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.10614"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1201622"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ng1296-457","article-title":"Use of a CDNA microarray to analyse gene expression","volume":"14","author":"derisi","year":"1996","journal-title":"Nat Genet"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2012.07.092"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp053"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.02.105"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-9-S5-S4"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1159\/000374030"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-016-1062-1"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0582"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.7.6.863"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbx017"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4161\/sysb.22816"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.03058.x"},{"key":"ref5","first-page":"47","article-title":"Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction","volume":"8","author":"boolell","year":"1996","journal-title":"International Journal of Impotence Research"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2007.00136.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1145\/3307339.3342132"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078700"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1039\/c3mb25382a"},{"key":"ref49","first-page":"279","article-title":"Resveratrol down-regulates survivin and induces apoptosis in human multidrug-resistant SPC-A-1\/CDDP cells","volume":"23","author":"zhao","year":"2010","journal-title":"Oncol Rep"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26006"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2008.00436.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132939"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/0377-0427(87)90125-7"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703863"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181ec1729"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/4.2.249"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-236"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1607591"}],"container-title":["IEEE\/ACM Transactions on Computational Biology and Bioinformatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/8857\/9747964\/09178456.pdf?arnumber=9178456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T18:32:54Z","timestamp":1722537174000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/9178456\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":89,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1109\/tcbb.2020.3019781","relation":{},"ISSN":["1545-5963","1557-9964","2374-0043"],"issn-type":[{"value":"1545-5963","type":"print"},{"value":"1557-9964","type":"electronic"},{"value":"2374-0043","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,1]]}}}