{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T09:08:15Z","timestamp":1768468095918,"version":"3.49.0"},"reference-count":46,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"6","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"name":"Research Grants Council of the Hong Kong SAR","award":["CUHK14303819"],"award-info":[{"award-number":["CUHK14303819"]}]},{"name":"Innovation Technology Commission of the Hong Kong SAR","award":["MHP\/033\/20"],"award-info":[{"award-number":["MHP\/033\/20"]}]},{"name":"National Key Research and Development Program of China","award":["2021YFA0910700"],"award-info":[{"award-number":["2021YFA0910700"]}]},{"name":"International Collaboration Science Program for Biological Computation"},{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005407","name":"Food and Health Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005407","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Government of the Hong Kong Special Administrative Region","award":["COVID190117"],"award-info":[{"award-number":["COVID190117"]}]},{"name":"Government of the Hong Kong Special Administrative Region","award":["COVID1903010"],"award-info":[{"award-number":["COVID1903010"]}]},{"name":"Government of the Hong Kong Special Administrative Region","award":["T-11-709\/21-N"],"award-info":[{"award-number":["T-11-709\/21-N"]}]},{"name":"Emergency COVID-19","award":["2021YFC0866100"],"award-info":[{"award-number":["2021YFC0866100"]}]},{"name":"National Key Research and Development Program of China"},{"DOI":"10.13039\/501100007162","name":"Guangdong Science and Technology Department","doi-asserted-by":"publisher","award":["2020B1212030004"],"award-info":[{"award-number":["2020B1212030004"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"name":"L&amp;T Charitable Foundation"},{"name":"Guangdong Introducing Innovative and Entrepreneurial Teams","award":["2019BT02Y198"],"award-info":[{"award-number":["2019BT02Y198"]}]},{"name":"Shenzhen Key Laboratory for Cancer Metastasis and Personalized Therapy","award":["ZDSYS20210623091811035"],"award-info":[{"award-number":["ZDSYS20210623091811035"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE\/ACM Trans. Comput. Biol. and Bioinf."],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1109\/tcbb.2023.3311444","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T18:28:40Z","timestamp":1693852120000},"page":"3669-3680","source":"Crossref","is-referenced-by-count":4,"title":["Family-Specific Training Improves Linear B Cell Epitope Prediction for Emerging Viruses"],"prefix":"10.1109","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3627-3994","authenticated-orcid":false,"given":"Ran","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Statistics, The Chinese University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7834-1476","authenticated-orcid":false,"given":"Ye-Fan","family":"Hu","sequence":"additional","affiliation":[{"name":"Li Ka Shing Faculty of Medicine, School of Biomedical Sciences, The University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0456-3988","authenticated-orcid":false,"given":"Jin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Statistics, The Chinese University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8716-2306","authenticated-orcid":false,"given":"Bao-Zhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7114-0305","authenticated-orcid":false,"given":"Thomas","family":"Yau","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2744-9030","authenticated-orcid":false,"given":"Xiaodan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Statistics, The Chinese University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7531-2816","authenticated-orcid":false,"given":"Jian-Dong","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008790"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.03.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0377-z"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81749-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-020-01437-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1008237"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1110\/ps.062405906"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002829"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-514"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.890943"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1745-7580-2-2","article-title":"Improved method for predicting linear B-cell epitopes","volume":"2","author":"Larsen","year":"2006","journal-title":"Immunome Res."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1021\/bi00367a013"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx346"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062216"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2022.11.009"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063210"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6406-2_17"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5923\/j.bioinformatics.20110101.02"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01282-0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.56.091103.134135"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051215-031152"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0118-9"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0714-0"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.52.110405.091454"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/nri3916"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1701402"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ento.53.103106.093258"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.8.3718-3726.2005"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.6.4050"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.11.5309-5314.2004"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0366-x"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1066"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa0698"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(81)90087-5"},{"key":"ref36","article-title":"Biostrings: Efficient manipulation of biological strings","author":"Pag\u00e8s","year":"2019"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1137\/1109020"},{"issue":"4","key":"ref38","first-page":"359","article-title":"Smooth regression analysis","volume":"26","author":"Watson","year":"1964","journal-title":"Sankhy\u0101: Indian J. Statist. Ser. A (1961\u20132002)"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-18021-1"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-12-104"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty463"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500527"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1100"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1290"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/8.3.275"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msy096"}],"container-title":["IEEE\/ACM Transactions on Computational Biology and Bioinformatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/8857\/10373680\/10238778.pdf?arnumber=10238778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T02:40:50Z","timestamp":1705027250000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/10238778\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":46,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1109\/tcbb.2023.3311444","relation":{},"ISSN":["1545-5963","1557-9964","2374-0043"],"issn-type":[{"value":"1545-5963","type":"print"},{"value":"1557-9964","type":"electronic"},{"value":"2374-0043","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11]]}}}