{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T04:10:28Z","timestamp":1744171828501,"version":"3.40.3"},"reference-count":35,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"name":"Research Funds of Jiont Research Center for Occupational Medicine and Health of IHM"},{"name":"Peng Cheng Laboratory and Peng Cheng Cloud-Brain"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42177417"],"award-info":[{"award-number":["42177417"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Foundation for High-level Talents of Anhui University of Science and Technology","award":["YJ20240007"],"award-info":[{"award-number":["YJ20240007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Trans. Comput. Biol. Bioinform."],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1109\/tcbbio.2025.3547383","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T18:45:37Z","timestamp":1741113937000},"page":"946-955","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of Bioactive Constituents for Colitis From Traditional Chinese Medicine Prescription via Deep Neural Network"],"prefix":"10.1109","volume":"22","author":[{"given":"Zhixiang","family":"Ren","sequence":"first","affiliation":[{"name":"Peng Cheng Laboratory, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6120-2945","authenticated-orcid":false,"given":"Yiming","family":"Ren","sequence":"additional","affiliation":[{"name":"Peng Cheng Laboratory, Shenzhen, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Shu","sequence":"additional","affiliation":[{"name":"Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism and Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Joint Research Center for Occupational Medicine and Health of IHM and School of Public Health, Anhui University of Science and, Technology, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9009-3786","authenticated-orcid":false,"given":"Huan","family":"Xu","sequence":"additional","affiliation":[{"name":"Joint Research Center for Occupational Medicine and Health of IHM and School of Public Health, Anhui University of Science and, Technology, Hefei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01464"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i1.91"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2021.01.026"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s1734-1140(11)70575-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.684486"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153709"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105187"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21050559"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-6-13"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153336"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112128"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154268"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbab106"},{"article-title":"Fast graph representation learning with PyTorch geometric","year":"2019","author":"Fey","key":"ref14"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1145\/2939672.2939754"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.2002.02044"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1145\/3097983.3098036"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-93037-4_16"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-93417-4_38"},{"article-title":"Composition- based multi-relational graph convolutional networks","year":"2019","author":"Vashishth","key":"ref20"},{"key":"ref21","first-page":"2022","article-title":"Hetero- geneous graph attention network","volume-title":"Proc. World Wide Web Conf.","author":"Wang"},{"article-title":"Graph attention networks","year":"2017","author":"Velickovi \u0301c","key":"ref22"},{"year":"2018","key":"ref23","article-title":"Stellar - ml v0.2.0: Machine learning on graphs"},{"key":"ref24","first-page":"1025","article-title":"Inductive representation learning on large graphs","volume-title":"Proc. Adv. Neural Inf. Process. Syst.","author":"Hamilton"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.csbj.2024.04.016","article-title":"Tcmm: A unified database for traditional Chinese medicine modernization and therapeu- tic innovations","volume":"23","author":"Zhixiang","year":"2024.","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.477"},{"issue":"9853","key":"ref27","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Ord \u0301as","journal-title":"Lancet"},{"key":"ref28","article-title":"Traditional Chinese medicine prescrip-tion shenling baizhu powder to treat ulcerative colitis: Clinical evidence and potential mechanisms","volume":"1","author":"Chen","year":"2023","journal-title":"Herbal Medicines Gastrointestinal Hepatic Dis.-Novel Pharmacological Toxicological Approaches"},{"key":"ref29","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114281","article-title":"Metabolomics of spleen-yang deficiency syndrome and the therapeutic effect of fuzi lizhong pill on regulating endogenous metabolism","volume":"278","author":"Zhang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000023703"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.1002\/jcb.27853","article-title":"-sitosterol improves experimental colitis in mice with a target against pathogenic bacteria","volume":"120","author":"Ding","year":"2019","journal-title":"J. Cellular Biochem."},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071654"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2015.07.012"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.intimp.2015.10.024","article-title":"Oleanolic acid ameliorates dextran sodium sulfate-induced colitis in mice by restoring the balance of th17\/treg cells and inhibiting nf-b signaling pathway","volume":"29","author":"Kang","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2018.05.001"}],"container-title":["IEEE Transactions on Computational Biology and Bioinformatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/10723156\/10953288\/10909593.pdf?arnumber=10909593","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T05:20:42Z","timestamp":1744089642000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/10909593\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":35,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1109\/tcbbio.2025.3547383","relation":{},"ISSN":["2998-4165"],"issn-type":[{"type":"electronic","value":"2998-4165"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}