{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:34:09Z","timestamp":1755221649513,"version":"3.43.0"},"reference-count":36,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"name":"Ministry of Science and Innovation \/ State Research Agency"},{"name":"Spanish Society of Cardiology and the Spanish Heart Foundation"},{"name":"ELLIS Unit Madrid from the Autonomous Region of Madrid"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Trans. Comput. Biol. Bioinform."],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1109\/tcbbio.2025.3572833","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T13:54:56Z","timestamp":1748267696000},"page":"1822-1835","source":"Crossref","is-referenced-by-count":0,"title":["Discovering Genetic Variants in Hypertrophic Cardiomyopathy With Multiple Machine Learning Techniques"],"prefix":"10.1109","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4521-0031","authenticated-orcid":false,"given":"Dafne","family":"Lozano-Paredes","sequence":"first","affiliation":[{"name":"Department of Signal Theory and Communications, Telematics, and Computing Systems, Universidad Rey Juan Carlos, Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8845-2834","authenticated-orcid":false,"given":"Luis","family":"Bote-Curiel","sequence":"additional","affiliation":[{"name":"Department of Signal Theory and Communications, Telematics, and Computing Systems, Universidad Rey Juan Carlos, Madrid, Spain"}]},{"given":"Mar\u00eda","family":"Sabater-Molina","sequence":"additional","affiliation":[{"name":"Cardiogenetics Laboratory, Instituto Murciano de Investigación Biosanitaria, Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7109-2668","authenticated-orcid":false,"given":"Concha","family":"Bielza","sequence":"additional","affiliation":[{"name":"Department of Artificial Intelligence, Universidad Politécnica de Madrid, Madrid, Spain"}]},{"given":"Juan R","family":"Gimeno-Blanes","sequence":"additional","affiliation":[{"name":"Familiar Cardiopathies Unit, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1356-2646","authenticated-orcid":false,"given":"Sergio","family":"Mu\u00f1oz-Romero","sequence":"additional","affiliation":[{"name":"Department of Signal Theory and Communications, Telematics, and Computing Systems, Universidad Rey Juan Carlos, Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2727-2132","authenticated-orcid":false,"given":"F Javier","family":"Gimeno-Blanes","sequence":"additional","affiliation":[{"name":"Department of Signal Theory and Communications, Universidad Miguel Hernández, Alicante, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0652-9872","authenticated-orcid":false,"given":"Pedro","family":"Larra\u00f1aga","sequence":"additional","affiliation":[{"name":"Department of Artificial Intelligence, Universidad Politécnica de Madrid, Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0426-8912","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Rojo-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Signal Theory and Communications, Telematics, and Computing Systems, Universidad Rey Juan Carlos, Madrid, Spain"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311059"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13027"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.129841"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5935\/abc.20140022"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12010225"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat5056"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.04.078"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.975478"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7861\/fhj.2021-0095"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.119.007952"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA119.001586"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/03000605231213781"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.22489\/CinC.2023.172"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.182"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3706"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/BF00994018"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2361"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.patcog.2019.107077"},{"volume-title":"Probabilistic Reasoning in Intelligent Systems: Networks of Plausible Inference","year":"1988","author":"Pearl","key":"ref19"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1037\/h0070888"},{"key":"ref21","first-page":"833","article-title":"Stochastic neighbor embedding","volume-title":"Proc. Adv. Neural Inf. Process. Syst.","author":"Hinton"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.21105\/joss.00861"},{"key":"ref23","first-page":"4768","article-title":"A unified approach to interpreting model predictions","volume-title":"Proc. 31st Int. Conf. Neural Inf. Process. Syst.","author":"Lundberg"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2016.06.020"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.200402"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr330"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/npg.els.0005005"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1828-7"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.2307\/2340521"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.2307\/2282330"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.2307\/4615733"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1936.tb02137.x"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-2404-4_12"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.059631"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3390\/cells11213511"}],"container-title":["IEEE Transactions on Computational Biology and Bioinformatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/10723156\/11121392\/11015630.pdf?arnumber=11015630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T05:01:09Z","timestamp":1754715669000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11015630\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":36,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1109\/tcbbio.2025.3572833","relation":{},"ISSN":["2998-4165"],"issn-type":[{"type":"electronic","value":"2998-4165"}],"subject":[],"published":{"date-parts":[[2025,7]]}}}