{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:57:14Z","timestamp":1765479434031,"version":"3.48.0"},"reference-count":51,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61972299"],"award-info":[{"award-number":["61972299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62372342"],"award-info":[{"award-number":["62372342"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62071456"],"award-info":[{"award-number":["62071456"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hubei Province Natural Science Foundation of China","award":["2024AFB865"],"award-info":[{"award-number":["2024AFB865"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Trans. Comput. Biol. Bioinform."],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1109\/tcbbio.2025.3596120","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T18:06:23Z","timestamp":1754417183000},"page":"2526-2539","source":"Crossref","is-referenced-by-count":0,"title":["An Efficient Targeted Drug Design Method Using Framework of Multiscale Encoder-Decoder"],"prefix":"10.1109","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2507-2540","authenticated-orcid":false,"given":"Haoran","family":"Liu","sequence":"first","affiliation":[{"name":"School of Computer Science and Technology, Wuhan University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5595-4966","authenticated-orcid":false,"given":"Xiaoli","family":"Lin","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology, Wuhan University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1348-8773","authenticated-orcid":false,"given":"Jing","family":"Hu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology, Wuhan University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Computer Science and Technology, Wuhan University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8193-6956","authenticated-orcid":false,"given":"Jun","family":"Pang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology, Wuhan University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5615-2044","authenticated-orcid":false,"given":"Xiaolong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Intelligent Information Processing and Real-Time Industrial System, School of Computer Science and Technology, Wuhan University of Science and Technology, Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1038\/s41586-023-06887-8"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1093\/bib\/bbac526"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1002\/wcms.1104"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1016\/j.jhealeco.2016.01.012"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1007\/978-3-031-13829-4_37"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1021\/acscentsci.7b00512"},{"key":"ref7","first-page":"7192","article-title":"GraphDF: A discrete flow model for molecular graph generation","volume-title":"Proc. Int. Conf. Mach. Learn.","author":"Luo"},{"key":"ref8","first-page":"6229","article-title":"A 3D generative model for structure-based drug design","volume-title":"Proc. Adv. Neural Inf. Process. Syst.","author":"Luo"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.18632\/oncotarget.14073"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad235","article-title":"Comprehensive evaluation of deep and graph learning on drug-drug interactions prediction","volume":"24","author":"Lin","year":"2023","journal-title":"Brief. Bioinf."},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1021\/acs.jcim.2c01301"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1186\/s13321-023-00702-2"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1109\/BIBM58861.2023.10385838"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1186\/s13321-020-00419-6"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.24963\/ijcai.2020\/380"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1109\/TCBB.2018.2871674"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1109\/TCBB.2022.3149791"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.1109\/TCBB.2019.2931717"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1093\/bib\/bbad383"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1109\/TCBB.2022.3206907"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1016\/j.patcog.2022.109234"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1093\/nar\/gkr777"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1093\/bioinformatics\/btac793"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.1093\/nar\/28.1.235"},{"doi-asserted-by":"publisher","key":"ref25","DOI":"10.1155\/2012\/321653"},{"doi-asserted-by":"publisher","key":"ref26","DOI":"10.1016\/j.cell.2021.01.027"},{"doi-asserted-by":"publisher","key":"ref27","DOI":"10.1021\/acs.jmedchem.1c01601"},{"doi-asserted-by":"publisher","key":"ref28","DOI":"10.1074\/jbc.M314086200"},{"doi-asserted-by":"publisher","key":"ref29","DOI":"10.1007\/s13238-015-0181-1"},{"doi-asserted-by":"publisher","key":"ref30","DOI":"10.1126\/science.abb3405"},{"doi-asserted-by":"publisher","key":"ref31","DOI":"10.1038\/s41586-020-2368-8"},{"doi-asserted-by":"publisher","key":"ref32","DOI":"10.1038\/s41467-021-21060-3"},{"doi-asserted-by":"publisher","key":"ref33","DOI":"10.1021\/acsmedchemlett.8b00173"},{"doi-asserted-by":"publisher","key":"ref34","DOI":"10.1021\/ja3090065"},{"doi-asserted-by":"publisher","key":"ref35","DOI":"10.1021\/bi00037a006"},{"doi-asserted-by":"publisher","key":"ref36","DOI":"10.1038\/s41467-023-43822-x"},{"doi-asserted-by":"publisher","key":"ref37","DOI":"10.1038\/s41594-021-00654-x"},{"doi-asserted-by":"publisher","key":"ref38","DOI":"10.1021\/acs.jmedchem.5b01267"},{"doi-asserted-by":"publisher","key":"ref39","DOI":"10.1038\/s41467-022-33121-2"},{"doi-asserted-by":"publisher","key":"ref40","DOI":"10.1093\/nar\/gkab1061"},{"doi-asserted-by":"publisher","key":"ref41","DOI":"10.48550\/ARXIV.1706.03762"},{"doi-asserted-by":"publisher","key":"ref42","DOI":"10.1002\/jcc.21256"},{"doi-asserted-by":"publisher","key":"ref43","DOI":"10.1002\/jcc.21334"},{"doi-asserted-by":"publisher","key":"ref44","DOI":"10.1093\/nar\/gkab255"},{"doi-asserted-by":"publisher","key":"ref45","DOI":"10.1016\/j.compbiomed.2023.107285"},{"doi-asserted-by":"publisher","key":"ref46","DOI":"10.1093\/pnasnexus\/pgac227"},{"key":"ref47","first-page":"7405","article-title":"De novo drug design using reinforcement learning with multiple GPT agents","volume-title":"Proc. Adv. Neural Inf. Process. Syst.","author":"Hu"},{"doi-asserted-by":"publisher","key":"ref48","DOI":"10.1021\/acs.jcim.4c01193"},{"doi-asserted-by":"publisher","key":"ref49","DOI":"10.1186\/s12859-024-05822-6"},{"doi-asserted-by":"publisher","key":"ref50","DOI":"10.4155\/fmc-2020-0262"},{"doi-asserted-by":"publisher","key":"ref51","DOI":"10.1038\/s41467-024-47011-2"}],"container-title":["IEEE Transactions on Computational Biology and Bioinformatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/10723156\/11296745\/11113248.pdf?arnumber=11113248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:44:43Z","timestamp":1765478683000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11113248\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":51,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1109\/tcbbio.2025.3596120","relation":{},"ISSN":["2998-4165"],"issn-type":[{"type":"electronic","value":"2998-4165"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}