{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:57:50Z","timestamp":1765479470984,"version":"3.48.0"},"reference-count":37,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Trans. Comput. Biol. Bioinform."],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1109\/tcbbio.2025.3598449","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T18:18:43Z","timestamp":1757096323000},"page":"2630-2641","source":"Crossref","is-referenced-by-count":2,"title":["A Computational Framework for Optimal and Model Predictive Control of Stochastic Gene Regulatory Networks"],"prefix":"10.1109","volume":"22","author":[{"given":"Hamza","family":"Faquir","sequence":"first","affiliation":[{"name":"Institute for Integrative Systems Biology (I2SysBio), CSIC-Universitat de Val&#x00E8;ncia, Paterna, Spain"}]},{"given":"Manuel","family":"P\u00e1jaro","sequence":"additional","affiliation":[{"name":"Universidade de Vigo, Department of Mathematics, Campus Ourense, Ourense, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2895-997X","authenticated-orcid":false,"given":"Irene","family":"Otero-Muras","sequence":"additional","affiliation":[{"name":"Institute for Integrative Systems Biology (I2SysBio), CSIC-Universitat de Val&#x00E8;ncia, Paterna, Spain"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1109\/MCS.2018.2810459"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coisb.2021.100397"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1109\/CDC40024.2019.9030209"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2022.102837"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2023.102893"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.0c00463"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2021.05.004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1321-1"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01498-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.9b00464"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.23919\/ECC57647.2023.10178155"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29888-z"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.5b00135"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206810109"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12546"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-021-00878-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2122132119"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1032-9_10"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2017.03.017"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.3c00033"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.23919\/IConAC.2018.8749012"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4236\/am.2016.716162"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1063\/1.481811"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12344-w"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifacol.2022.08.031"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.23919\/ECC64448.2024.10591020"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-85729-501-9_3"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s00285-018-1277-z"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1090\/gsm\/112"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ifacol.2022.08.029"},{"key":"ref31","article-title":"Computational optimization of systems governed by partial differential equations","volume-title":"Computational Science and Engineering","author":"Borz","year":"2012"},{"issue":"1","key":"ref32","first-page":"35","article-title":"A survey of nonlinear conjugate gradient methods","volume":"2","author":"Hager","year":"2006","journal-title":"Pacific J. Optim."},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1137\/030601880"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.92.032712"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s11538-023-01251-3"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btad682"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46361-1"}],"container-title":["IEEE Transactions on Computational Biology and Bioinformatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/10723156\/11296745\/11152678.pdf?arnumber=11152678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T18:44:55Z","timestamp":1765478695000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11152678\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":37,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1109\/tcbbio.2025.3598449","relation":{},"ISSN":["2998-4165"],"issn-type":[{"type":"electronic","value":"2998-4165"}],"subject":[],"published":{"date-parts":[[2025,11]]}}}