{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T20:05:00Z","timestamp":1780949100005,"version":"3.54.1"},"reference-count":50,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"name":"research project","award":["32170654"],"award-info":[{"award-number":["32170654"]}]},{"name":"research project","award":["32000464"],"award-info":[{"award-number":["32000464"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016588","name":"Shenzhen Research Institute, City University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016588","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Grants Council of the Hong Kong Special Administrative Region","award":["CityU 11203723"],"award-info":[{"award-number":["CityU 11203723"]}]},{"DOI":"10.13039\/100007567","name":"City University of Hong Kong","doi-asserted-by":"publisher","award":["CityU 7030022"],"award-info":[{"award-number":["CityU 7030022"]}],"id":[{"id":"10.13039\/100007567","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007567","name":"City University of Hong Kong","doi-asserted-by":"publisher","award":["C1056-24 G"],"award-info":[{"award-number":["C1056-24 G"]}],"id":[{"id":"10.13039\/100007567","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007567","name":"City University of Hong Kong","doi-asserted-by":"publisher","award":["CityU 9667265"],"award-info":[{"award-number":["CityU 9667265"]}],"id":[{"id":"10.13039\/100007567","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","award":["ITB\/FBL\/9037\/22\/S"],"award-info":[{"award-number":["ITB\/FBL\/9037\/22\/S"]}],"id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Trans. Comput. Biol. Bioinform."],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1109\/tcbbio.2026.3669919","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T20:51:27Z","timestamp":1772571087000},"page":"1148-1159","source":"Crossref","is-referenced-by-count":0,"title":["METRON: Metabolic Dynamic Perception Kolmogorov-Arnold Network for Biological Age Estimation"],"prefix":"10.1109","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8656-3064","authenticated-orcid":false,"given":"Zhongshen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Computer Science, City University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8163-3253","authenticated-orcid":false,"given":"Jixiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Computer Science, City University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"You","sequence":"additional","affiliation":[{"name":"Department of Computer Science, City University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1026-4499","authenticated-orcid":false,"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Software, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2303-492X","authenticated-orcid":false,"given":"Luyang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Computer Science, City University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Biological Science and Medical Engineering, Southeast University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1444-190X","authenticated-orcid":false,"given":"Leyi","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Software, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1985-938X","authenticated-orcid":false,"given":"Junkai","family":"Ji","sequence":"additional","affiliation":[{"name":"School of Artificial Intelligence, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2415-0401","authenticated-orcid":false,"given":"Qiuzhen","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8716-9823","authenticated-orcid":false,"given":"Xiangtao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Artificial Intelligence, Jilin University, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6062-733X","authenticated-orcid":false,"given":"Ka-Chun","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Computer Science, City University of Hong Kong, Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172539"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(19)30019-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-023-00866-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/biom12010039"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101050"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add6155"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-022-00511-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt2624"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1167\/jov.21.10.17"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101551"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)90950-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2005.040816"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05456-z"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07148-y"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0673-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-10-r115"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2023.107686"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102900"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls233"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly005"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29268-7"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.53941\/hm.2025.100014"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-024-00348-2"},{"key":"ref25","article-title":"KAN: Kolmogorov-Arnold networks","volume-title":"Proc. Int. Conf. Learn. Representations","author":"Liu","year":"2025"},{"key":"ref26","article-title":"Kolmogorov-Arnold transformer","volume-title":"Proc. Int. Conf. Learn. Representations","author":"Yang","year":"2025"},{"key":"ref27","article-title":"DeformTime: Capturing variable dependencies with deformable attention for time series forecasting","author":"Shu","year":"2025","journal-title":"Trans. Mach. Learn. Res."},{"key":"ref28","first-page":"333","article-title":"Die kinetik der invertinwirkung","volume":"49","author":"Michaelis","year":"1913","journal-title":"Biochem. Z"},{"key":"ref29","volume-title":"Mathematical Biology: I. An Introduction","volume":"17","author":"Murray","year":"2007"},{"key":"ref30","first-page":"iv","article-title":"The possible effects of the aggregation of the molecules of hemoglobin on its dissociation curves","volume":"40","author":"Hill","year":"1910","journal-title":"J. Physiol."},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1201\/9780429283321"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1996.tb02080.x"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/wics.14"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4302-5990-9_4"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucom.2017.04.018"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.29172\/7c2a6982-6d72-4cd8-bba6-2fccb06a7011"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-9473(01)00065-2"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1145\/2939672.2939785"},{"key":"ref39","first-page":"3146","article-title":"LightGBM: A highly efficient gradient boosting decision tree","volume-title":"Proc. Adv. Neural Inf. Process. Syst.","volume":"30","author":"Ke","year":"2017"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1038\/nature14539"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3115\/v1\/d14-1181"},{"key":"ref42","first-page":"18932","article-title":"Revisiting deep learning models for tabular data","volume-title":"Proc. Adv. Neural Inf. Process. Syst.","volume":"34","author":"Gorishniy","year":"2021"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59964-z"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adp3743"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102229"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.102063"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.8.4279"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-861552"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0760"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.21.3.0398"}],"container-title":["IEEE Transactions on Computational Biology and Bioinformatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/10723156\/11552635\/11419660.pdf?arnumber=11419660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T19:51:02Z","timestamp":1780948262000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11419660\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":50,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1109\/tcbbio.2026.3669919","relation":{},"ISSN":["2998-4165"],"issn-type":[{"value":"2998-4165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]}}}