{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:43:40Z","timestamp":1769553820104,"version":"3.49.0"},"reference-count":36,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62171106"],"award-info":[{"award-number":["62171106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62472322"],"award-info":[{"award-number":["62472322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Municipal Government of Quzhou","award":["2023D031"],"award-info":[{"award-number":["2023D031"]}]},{"name":"Municipal Government of Quzhou","award":["2024D010"],"award-info":[{"award-number":["2024D010"]}]},{"name":"Municipal Government of Quzhou","award":["2024D065"],"award-info":[{"award-number":["2024D065"]}]},{"name":"Municipal Government of Quzhou","award":["2024D068"],"award-info":[{"award-number":["2024D068"]}]},{"name":"Incubation Program for Innovative Science and Technology in the University of Electronic Science and Technology of China","award":["Y03023206100209"],"award-info":[{"award-number":["Y03023206100209"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Trans. Emerg. Top. Comput. Intell."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1109\/tetci.2025.3569765","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T14:08:03Z","timestamp":1748268483000},"page":"4133-4144","source":"Crossref","is-referenced-by-count":2,"title":["In Vivo Computational Strategy for Tumor Targeting in Co-Associated Biological Landscapes"],"prefix":"10.1109","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1926-8141","authenticated-orcid":false,"given":"Shaolong","family":"Shi","sequence":"first","affiliation":[{"name":"Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People&#x0027;s Hospital, Quzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, Quzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1123-6193","authenticated-orcid":false,"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, Quzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0786-0671","authenticated-orcid":false,"given":"Qingfu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Computer Science, City University of Hong Kong, Hong Kong, SAR, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7645-623X","authenticated-orcid":false,"given":"Yifan","family":"Chen","sequence":"additional","affiliation":[{"name":"Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, Quzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.01.021"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201803924"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc4308"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-021-01042-y"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1006-1211"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2614"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10143"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2017.05.011"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.14"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1109\/TNB.2019.2956470"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1109\/TEVC.2007.892759"},{"key":"ref12","volume-title":"An Introduction to Optimization: With Applications to Machine Learning","author":"Chong","year":"2023"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1109\/TEVC.2022.3198086"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3109\/10739689709146803"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-43093-1_4"},{"issue":"23","key":"ref16","first-page":"6449","article-title":"Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review","volume":"49","author":"Vaupel","year":"1989","journal-title":"Cancer Res."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1109\/TCYB.2020.3025859"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1109\/TCYB.2021.3052731"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.swevo.2021.100931"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1109\/TNB.2022.3149960"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.109160"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1109\/TMBMC.2024.3361251"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1109\/JIOT.2023.3272213"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1109\/TCYB.2020.3024868"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1109\/TNB.2020.3042266"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC46164.2021.9630546"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0530278100"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.06.081"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.01.043"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0099"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1201\/9780203852569"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1038\/nature10888"},{"key":"ref33","first-page":"1118","article-title":"Different races have different immune microenvironments: Comparison of white and Asian patients with liver cancer","volume":"13","author":"Gui-Min","year":"2023","journal-title":"Amer. J. Cancer Res."},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-009-8219-2_4"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0014-x"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.01.013"}],"container-title":["IEEE Transactions on Emerging Topics in Computational Intelligence"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/7433297\/11267152\/11015805.pdf?arnumber=11015805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T06:07:24Z","timestamp":1764050844000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11015805\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":36,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1109\/tetci.2025.3569765","relation":{},"ISSN":["2471-285X"],"issn-type":[{"value":"2471-285X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]}}}