{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T21:05:26Z","timestamp":1781211926102,"version":"3.54.1"},"reference-count":47,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"DOI":"10.13039\/100000001","name":"NSF","doi-asserted-by":"publisher","award":["1763523"],"award-info":[{"award-number":["1763523"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"NSF","doi-asserted-by":"publisher","award":["1747778"],"award-info":[{"award-number":["1747778"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"NSF","doi-asserted-by":"publisher","award":["1733843"],"award-info":[{"award-number":["1733843"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"NSF","doi-asserted-by":"publisher","award":["1703883"],"award-info":[{"award-number":["1703883"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Trans. Med. Imaging"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1109\/tmi.2020.3002244","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T22:37:36Z","timestamp":1592260656000},"page":"3655-3666","source":"Crossref","is-referenced-by-count":187,"title":["Weakly Supervised Deep Nuclei Segmentation Using Partial Points Annotation in Histopathology Images"],"prefix":"10.1109","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4260-3809","authenticated-orcid":false,"given":"Hui","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengxiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingru","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7128-1696","authenticated-orcid":false,"given":"Zhennan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8136-9816","authenticated-orcid":false,"given":"Kang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Riedlinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhajyoti","family":"De","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris N.","family":"Metaxas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2016.2621185"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1109\/ICCV.2015.191"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1109\/ICCV.2017.244"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1109\/ISBI.2019.8759457"},{"key":"ref31","first-page":"383","article-title":"Robust cell detection and segmentation in histopathological images using sparse reconstruction and stacked denoising autoencoders","author":"su","year":"2015","journal-title":"Proc Int Conf Med Image Comput Comput -Assist Intervent"},{"key":"ref30","first-page":"842","article-title":"Signet ring cell detection with a semi-supervised learning framework","author":"li","year":"2019","journal-title":"Proc Int Conf Inf Process Med Imag"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1109\/CVPR.2016.344"},{"key":"ref36","first-page":"549","article-title":"What’s the point: Semantic segmentation with point supervision","author":"bearman","year":"2016","journal-title":"Proc Eur Conf Comput Vis"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1109\/ICCV.2015.209"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1109\/ICCV.2015.203"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2017.2677499"},{"key":"ref40","first-page":"352","article-title":"Deep learning based instance segmentation in 3D biomedical images using weak annotation","author":"zhao","year":"2018","journal-title":"Proc Int Conf Med Image Comput Comput -Assist Intervent"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1109\/ISBI.2017.7950669"},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.1109\/TMI.2019.2927182","article-title":"Deep adversarial training for multi-organ nuclei segmentation in histopathology images","author":"mahmood","year":"2020","journal-title":"IEEE Trans Med Imag"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2018.2865709"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2018.12.003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1109\/CVPR.2019.00873"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-20351-1_30"},{"key":"ref17","first-page":"378","article-title":"Improving nuclei\/gland instance segmentation in histopathology images by full resolution neural network and spatial constrained loss","author":"qu","year":"2019","journal-title":"Proc Int Conf Med Image Comput Comput -Assist Intervent"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1109\/ISBI45749.2020.9098474"},{"key":"ref19","first-page":"1","article-title":"Semantic image segmentation with deep convolutional nets and fully connected CRFs","author":"chen","year":"2015","journal-title":"Proc Int Conf Learn Representations"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2017.07.003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2014.2361481"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1109\/CVPR.2015.7298965"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2016.2515127"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2009.2035102"},{"key":"ref29","first-page":"2652","article-title":"SFCN-OPI: Detection and fine-grained classification of nuclei using sibling FCN with objectness prior interaction","author":"zhou","year":"2018","journal-title":"Proc 32nd AAAI Conf Artif Intell"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070221"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2015.10.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2011.2141674"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/2153-3539.186902"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2015.2481436"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2009.2034865"},{"key":"ref46","article-title":"Adam: A method for stochastic optimization","author":"kingma","year":"2014","journal-title":"arXiv 1412 6980"},{"key":"ref20","article-title":"BoxNet: Deep learning based biomedical image segmentation using boxes only annotation","author":"yang","year":"2018","journal-title":"arXiv 1806 00593"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1109\/38.946629"},{"key":"ref22","first-page":"390","article-title":"Weakly supervised deep nuclei segmentation using points annotation in histopathology images","author":"qu","year":"2019","journal-title":"Proc Int Conf Med Imag with Deep Learn"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2015.2433900"},{"key":"ref21","first-page":"507","article-title":"On regularized losses for weakly-supervised cnn segmentation","author":"tang","year":"2018","journal-title":"Proc Eur Conf Comput Vis"},{"key":"ref42","first-page":"234","article-title":"U-net: Convolutional networks for biomedical image segmentation","author":"ronneberger","year":"2015","journal-title":"Proc Int Conf Med Image Comput Comput -Assist Intervent"},{"key":"ref24","first-page":"358","article-title":"Beyond classification: Structured regression for robust cell detection using convolutional neural network","author":"xie","year":"2015","journal-title":"Proc Int Conf Med Image Comput Comput -Assist Intervent"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2019.02.009"},{"key":"ref23","first-page":"411","article-title":"Mitosis detection in breast cancer histology images with deep neural networks","author":"cire?an","year":"2013","journal-title":"Proc Int Conf Med Image Comput Comput -Assist Intervent"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-8659.2009.01645.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2015.2458702"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1109\/CVPR.2016.90"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2016.2525803"}],"container-title":["IEEE Transactions on Medical Imaging"],"original-title":[],"link":[{"URL":"https:\/\/ieeexplore.ieee.org\/ielam\/42\/9242349\/9116833-aam.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/42\/9242349\/09116833.pdf?arnumber=9116833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T13:58:36Z","timestamp":1651067916000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/9116833\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":47,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.1109\/tmi.2020.3002244","relation":{},"ISSN":["0278-0062","1558-254X"],"issn-type":[{"value":"0278-0062","type":"print"},{"value":"1558-254X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]}}}