{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T07:54:14Z","timestamp":1772697254134,"version":"3.50.1"},"reference-count":44,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA275188"],"award-info":[{"award-number":["R01CA275188"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Trans. Med. Imaging"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1109\/tmi.2025.3618247","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:36:45Z","timestamp":1759772205000},"page":"1115-1126","source":"Crossref","is-referenced-by-count":2,"title":["LeqMod: Adaptable Lesion-Quantification-Consistent Modulation for Deep Learning Low-Count PET Image Denoising"],"prefix":"10.1109","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9503-1381","authenticated-orcid":false,"given":"Menghua","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1124-3548","authenticated-orcid":false,"given":"Huidong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yale University, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yale University, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2906-0897","authenticated-orcid":false,"given":"Bo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Yale University, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanzhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-736X","authenticated-orcid":false,"given":"Axel","family":"Rominger","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9651-5820","authenticated-orcid":false,"given":"Quanzheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramsey D.","family":"Badawi","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California Davis, Sacramento, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-3084","authenticated-orcid":false,"given":"Kuangyu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"El Fakhri","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7007-1037","authenticated-orcid":false,"given":"Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/51\/13\/R08"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2174\/1874471010902040224"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1109\/TRPMS.2023.3349194"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081390"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-020-01550-y"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.107.041871"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2014.2329702"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2013.05.005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s12194-024-00780-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ac783d"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/abcdea"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1109\/TRPMS.2023.3334276"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-021-05644-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2023.3336237"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-17247-2_8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1109\/TRPMS.2023.3334105"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2023.102993"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2021.3064926"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2023.3342809"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2023.3293836"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-43999-5_23"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-023-06417-8"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-43907-0_26"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.264826"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ab3242"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2022.107199"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2021.3061758"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucom.2020.10.077"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-66415-2_21"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-46723-8_49"},{"key":"ref31","first-page":"3576","article-title":"One size fits all: Can we train one denoiser for all noise levels?","volume-title":"Proc. Int. Conf. Mach. Learn.","author":"Gnansambandam"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12111148"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1109\/WACV51458.2022.00312"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1109\/TIP.2015.2499698"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1109\/ICCV.2017.244"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-022-01718-3"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-08999-2_22"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.18178\/ijmlc.2019.9.3.800"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2022.102614"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-34341-2"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.123.267048"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1186\/s40658-022-00470-2"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1109\/WACV45572.2020.9093475"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-72117-5_42"}],"container-title":["IEEE Transactions on Medical Imaging"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/42\/11421252\/11194243.pdf?arnumber=11194243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:55:17Z","timestamp":1772693717000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11194243\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":44,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1109\/tmi.2025.3618247","relation":{},"ISSN":["0278-0062","1558-254X"],"issn-type":[{"value":"0278-0062","type":"print"},{"value":"1558-254X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]}}}