{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T20:53:51Z","timestamp":1775508831041,"version":"3.50.1"},"reference-count":46,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["864313"],"award-info":[{"award-number":["864313"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Trans. Med. Imaging"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1109\/tmi.2025.3630705","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T18:48:17Z","timestamp":1762800497000},"page":"1592-1605","source":"Crossref","is-referenced-by-count":0,"title":["Derivation and Validation of Compartment Models: Implications for Dynamic Imaging"],"prefix":"10.1109","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7656-5838","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Kowalski","sequence":"first","affiliation":[{"name":"Saclay IDF Inria Research Center, Palaiseau, Inria, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8878-0616","authenticated-orcid":false,"given":"Lorenzo","family":"Sala","sequence":"additional","affiliation":[{"name":"INRAE, Université Paris-Saclay, Jouy-en-Josas, France"}]},{"given":"Dirk","family":"Drasdo","sequence":"additional","affiliation":[{"name":"Saclay IDF Inria Research Center, Palaiseau, Inria, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9754-4386","authenticated-orcid":false,"given":"Irene","family":"Vignon-Clementel","sequence":"additional","affiliation":[{"name":"Saclay IDF Inria Research Center, Palaiseau, Inria, France"}]}],"member":"263","reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/psp4.12134","article-title":"Applied concepts in PBPK modeling: How to build a PBPK\/PD model","volume":"5","author":"Kuepfer","year":"2016","journal-title":"CPT, Pharmacometrics Syst. Pharmacol."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ddmod.2017.09.002","article-title":"Modeling approaches for hepatic spatial heterogeneity in pharmacokinetic simulations","volume":"22","author":"Schwen","year":"2016","journal-title":"Drug Discovery Today, Disease Models"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-019-02492-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1049564"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1118\/1.3147145"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-010-1448-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10080"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-011-9734-9"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ejps.2018.01.008","article-title":"Model and methods to assess hepatic function from indocyanine green fluorescence dynamical measurements of liver tissue","volume":"115","author":"Audebert","year":"2018","journal-title":"Eur. J. Pharmaceutical Sci."},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.12793\/tcp.2019.27.1.19","article-title":"Evolving role of modeling and simulation in drug development","volume":"27","author":"Lim","year":"2019","journal-title":"Transl. Clin. Pharmacol."},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/bf02477493"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-013-9315-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22861"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2940"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.210.1.r99ja46269"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/2014jf003421"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","DOI":"10.1017\/S0022377824000163","article-title":"Mean-field transport equations and energy theorem for plasma edge turbulent transport","volume":"90","author":"Coosemans","year":"2024","journal-title":"J. Plasma Phys."},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1016\/j.bpj.2020.08.041","article-title":"Clot permeability, agonist transport, and platelet binding kinetics in arterial thrombosis","volume":"119","author":"Du","year":"2020","journal-title":"Biophysical J."},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/cnm.2847"},{"issue":"1","key":"ref20","first-page":"20568","article-title":"Effects of non-Newtonian viscosity on arterial and venous flow and transport","volume-title":"Sci. Rep.","volume":"12","author":"Lynch","year":"2022"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-3-031-58519-7_2","article-title":"A computational model of the tumor microenvironment applied to fractionated radiotherapy","volume":"36","author":"Possenti","year":"2024","journal-title":"Quantitative Approaches to Microcirculation"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fbinf.2023.977228"},{"key":"ref23","article-title":"Microvascular modeling for medical imaging and toxicity assessment","volume-title":"Quantitative Approaches to Microcirculation Mathematical Models, Computational Methods and Data Analysis","author":"Kowalski","year":"2023"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1109\/TMI.2014.2300450","article-title":"A tracer-kinetic field theory for medical imaging","volume":"33","author":"Sourbron","year":"2014","journal-title":"IEEE Trans. Med. Imag."},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1109\/TMI.2009.2031435","article-title":"Multiscale model of liver DCE-MRI towards a better understanding of tumor complexity","volume":"29","author":"Mescam","year":"2010","journal-title":"IEEE Trans. Med. Imag."},{"key":"ref26","volume-title":"An Introduction to Fluid Dynamics","author":"Batchelor","year":"1967"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-4612-2184-5_1","article-title":"Modeling in the analysis of the processes of uptake and metabolism in the whole organ","volume-title":"Whole Organ Approaches to Cellular Metabolism","author":"Bassingthwaighte","year":"1998"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jcct.2009.07.003","article-title":"What are the basic concepts of temporal, contrast, and spatial resolution in cardiac CT?","volume":"3","author":"Lin","year":"2009","journal-title":"J. Cardiovascular Comput. Tomogr."},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.1.74"},{"key":"ref30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2024.106831","article-title":"Taylor dispersion analysis for measurement of diffusivity and size of gadolinium-based contrast agents","volume":"200","author":"Somnin","year":"2024","journal-title":"Eur. J. Pharmaceutical Sci."},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1063\/1.3088050","article-title":"New international formulation for the viscosity of H2O","volume":"38","author":"Huber","year":"2009","journal-title":"J. Phys. Chem. Reference Data"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-013-0389-0"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2423060279"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.28.7.076001","article-title":"Mapping estimates of vascular permeability with a clinical indocyanine green fluorescence imaging system in experimental pancreatic adenocarcinoma tumors","volume":"28","author":"Reed","year":"2023","journal-title":"J. Biomed. Opt."},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1124\/jpet.110.166991","article-title":"Hepatic transport mechanisms of cholyl-l-lysyl-fluorescein","volume":"334","author":"de Waart","year":"2010","journal-title":"J. Pharmacol. Experim. Therapeutics"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-32494-1_4"},{"key":"ref37","article-title":"Cmaes: A simple yet practical Python library for CMA-ES","author":"Nomura","year":"2024","journal-title":"arXiv:2402.01373"},{"key":"ref38","article-title":"A comparative analysis of metamodels for lumped cardiovascular models, and pipeline for sensitivity analysis, parameter estimation, and uncertainty quantification","author":"Hanna","year":"2024","journal-title":"arXiv:2410.12654"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1109\/RBME.2016.2583541","article-title":"Mathematical models of contrast transport kinetics for cancer diagnostic imaging: A review","volume":"9","author":"Turco","year":"2016","journal-title":"IEEE Rev. Biomed. Eng."},{"issue":"7","key":"ref40","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.3174\/ajnr.A4712","article-title":"Evaluating permeability surface-area product as a measure of blood-brain barrier permeability in a murine model","volume":"37","author":"Weidman","year":"2016","journal-title":"Amer. J. Neuroradiol."},{"key":"ref41","first-page":"1235","article-title":"Spatial resolution effects on permeability-surface area estimation","volume-title":"Proc. 11th Ann. Meeting Intl. Soc. Mag. Reson. Med.","author":"Aref","year":"2003"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26518"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.106.054103"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.38.1.77"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.6.2889"},{"key":"ref46","first-page":"544","article-title":"Understanding organ vascular behavior through their architecture","volume-title":"Proc. 12th Int.  Conf. Complex Netw.  Appl.","author":"Kowalski"}],"container-title":["IEEE Transactions on Medical Imaging"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/42\/11474706\/11236420.pdf?arnumber=11236420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:56:37Z","timestamp":1775505397000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11236420\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":46,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1109\/tmi.2025.3630705","relation":{},"ISSN":["0278-0062","1558-254X"],"issn-type":[{"value":"0278-0062","type":"print"},{"value":"1558-254X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]}}}