{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:03:25Z","timestamp":1790420605645,"version":"4.1.0"},"reference-count":48,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"}],"funder":[{"DOI":"10.13039\/100003898","name":"DJF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003898","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007631","name":"CIFAR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007631","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MAB"},{"DOI":"10.13039\/501100000038","name":"NSERC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Trans. Pattern Anal. Mach. Intell."],"published-print":{"date-parts":[[2017,4,1]]},"DOI":"10.1109\/tpami.2016.2627573","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T20:03:00Z","timestamp":1478808180000},"page":"706-718","source":"Crossref","is-referenced-by-count":51,"title":["Building Proteins in a Day: Efficient 3D Molecular Structure Estimation with Electron Cryomicroscopy"],"prefix":"10.1109","volume":"39","author":[{"given":"Ali","family":"Punjani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus A.","family":"Brubaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Fleet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008935410038"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/wics.56"},{"key":"ref33","first-page":"623","article-title":"A fast natural Newton method","author":"le roux","year":"2010","journal-title":"Proc 27th Int Conf Mach Learn"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1162\/089976698300017746"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1162\/089976600300015420"},{"key":"ref30","first-page":"1139","article-title":"On the importance of initialization and\n momentum in deep learning","author":"sutskever","year":"2013","journal-title":"Proc 30th Int Conf Mach Learn"},{"key":"ref37","first-page":"2672","article-title":"A stochastic\n gradient method with an exponential convergence rate for strongly convex optimization with finite training sets","author":"le roux","year":"2012","journal-title":"Proc Advances Neural Inf Process Syst"},{"key":"ref36","article-title":"Microscopic advances with large-scale learning: Stochastic optimization for\n cryo-EM","author":"punjani","year":"2014","journal-title":"Proc Neural Inf Process Syst Workshop Mach Learn Comput Biol"},{"key":"ref35","first-page":"735","article-title":"Deep learning via Hessian-free optimization","author":"martens","year":"2010","journal-title":"Proc 27th Int Conf Mach Learn"},{"key":"ref34","first-page":"849","article-title":"Topmoumoute online natural gradient algorithm","author":"le roux","year":"2008","journal-title":"Proc Advances Neural Inf Process Syst"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2013.09.015"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-7-50"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2006.05.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2012.09.006"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2006.05.009"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2011.12.014"},{"key":"ref15","year":"2015"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nature10699"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1109\/CVPR.2015.7298929"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2014.03.001"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2012.12.010"},{"key":"ref28","first-page":"372","article-title":"A method of solving a convex programming problem with convergence\n rate O (1\/k2)","volume":"27","author":"nesterov","year":"1983","journal-title":"Soviet Math Doklady"},{"key":"ref4","first-page":"112","article-title":"A\n probabilistic theory of occupancy and emptiness","author":"bhotika","year":"2002","journal-title":"Proc 7th Eur Conf Comput Vis"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/BF03024331"},{"key":"ref3","author":"keeler","year":"2010","journal-title":"Understanding NMR Spectroscopy"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1109\/ICCV.2009.5459148"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/0041-5553(64)90137-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008191222954"},{"key":"ref8","author":"hsieh","year":"2003","journal-title":"Computed Tomography Principles Design Artifacts and Recent Advances"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2009.02.012"},{"key":"ref2","author":"rupp","year":"2009","journal-title":"Biomolecular Crystallography Principles Practice and Application to Structural Biology"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1145\/2185520.2185548"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/525172a"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2472"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1109\/CVPR.2006.295"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.2307\/2987782"},{"key":"ref48","author":"reimer","year":"2008","journal-title":"Transmission Electron Microscopy Physics of Image Formation"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth992"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6533-2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1006\/jsbi.1998.4014"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg608"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1145\/169711.169705"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2005.12.005"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq456"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1038\/41944"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1080\/01630560903163508"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-8477(03)00069-8"},{"key":"ref25","first-page":"477","article-title":"A quadrature formula for the sphere of the 131st algebraic order of accuracy","volume":"59","author":"lebedev","year":"1999","journal-title":"Doklady Math"}],"container-title":["IEEE Transactions on Pattern Analysis and Machine Intelligence"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/34\/7870775\/07740877.pdf?arnumber=7740877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T16:08:21Z","timestamp":1642003701000},"score":1,"resource":{"primary":{"URL":"http:\/\/ieeexplore.ieee.org\/document\/7740877\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,1]]},"references-count":48,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1109\/tpami.2016.2627573","relation":{},"ISSN":["0162-8828","2160-9292"],"issn-type":[{"value":"0162-8828","type":"print"},{"value":"2160-9292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,1]]}}}