{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:45:32Z","timestamp":1779205532475,"version":"3.51.4"},"reference-count":51,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/USG.html"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["#RR140013"],"award-info":[{"award-number":["#RR140013"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["#4 R00 LM011390-02"],"award-info":[{"award-number":["#4 R00 LM011390-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["#1R21CA21 4299-01"],"award-info":[{"award-number":["#1R21CA21 4299-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"US National Science Foundation","award":["IIS 1553329"],"award-info":[{"award-number":["IIS 1553329"]}]},{"name":"US National Science Foundation","award":["IIS 1553329"],"award-info":[{"award-number":["IIS 1553329"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Trans. Visual. Comput. Graphics"],"published-print":{"date-parts":[[2019,4,1]]},"DOI":"10.1109\/tvcg.2018.2818701","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T19:04:43Z","timestamp":1522177483000},"page":"1760-1773","source":"Crossref","is-referenced-by-count":10,"title":["Robust Tracing and Visualization of Heterogeneous Microvascular Networks"],"prefix":"10.1109","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7980-2791","authenticated-orcid":false,"given":"Pavel A.","family":"Govyadinov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5318-4470","authenticated-orcid":false,"given":"Tasha","family":"Womack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1549-4165","authenticated-orcid":false,"given":"Jason L.","family":"Eriksen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0581-6415","authenticated-orcid":false,"given":"Guoning","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3949-6133","authenticated-orcid":false,"given":"David","family":"Mayerich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref39","first-page":"147","article-title":"Superquadric tensor glyphs","author":"kindlmann","year":"2004","journal-title":"Proc 6th Joint Eurograph -IEEE TCVG Conf Vis"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cag.2011.01.011"},{"key":"ref33","first-page":"501","article-title":"The microvascular alterations in frontal cortex during treatment with antipsychotics: A post-mortem study","volume":"57","author":"udri?toiu","year":"2016","journal-title":"Rom J Morphol Embryol"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.04.003"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2016.03.015"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.10.014"},{"key":"ref37","article-title":"Extreme multi-resolution visualization: A challenge on many levels","author":"balme","year":"2015"},{"key":"ref36","doi-asserted-by":"crossref","DOI":"10.1145\/2487228.2487235","article-title":"VDB: High-resolution sparse volumes with dynamic topology","volume":"32","author":"museth","year":"2013","journal-title":"ACM Trans Graph"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2008.179"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2009.178"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038\/nm1210-1370"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.2.4"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R116.760215"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.10.011"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.161.3.3786721"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cma.2007.02.009"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023437403657"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1117\/12.237852"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucom.2014.07.059"},{"key":"ref23","first-page":"25","article-title":"Automated segmentation of coronary vessels in angiographic image sequences utilizing temporal, spatial, and structural constraints","author":"o'brien","year":"1994","journal-title":"Proc SPIE Vis Biomed Comput"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1005392"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2016.00082"},{"key":"ref50","article-title":"Scipy: Open source scientific tools for python","volume":"4","author":"jones","year":"2014"},{"key":"ref51","article-title":"Evaluation of multi-threading in vulkan","author":"blackert","year":"2016"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(98)80009-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1109\/TITB.2002.1006304"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2015.2467435"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2008.196"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.09.024"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.12.007"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00370-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1854"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2014.07.003"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2014.10.012"},{"key":"ref19","first-page":"-415i","article-title":"A segmentation-free approach for skeletonization of gray-scale images via anisotropic vector diffusion","author":"yu","year":"2004","journal-title":"Proc IEEE Comput Society Conf Comput Vis Pattern Recognit"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2010.01139.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.07.015"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104819"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"carmeliet","year":"2000","journal-title":"Nature"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1979"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2008.02024.x"},{"key":"ref49","article-title":"Spherical harmonic lighting: The gritty details","author":"green","year":"2003","journal-title":"Proc Archives of the Game Developers Conf"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.12.007"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0156"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03418.x"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012387582-2\/50040-X"},{"key":"ref47","first-page":"952","article-title":"Mean diffusivity and fractional anisotropy histograms of patients with multiple sclerosis","volume":"22","author":"cercignani","year":"2001","journal-title":"Amer J Neuroradiology"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088067"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1111\/cgf.12890"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-S8-S7"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1145\/325165.325242"}],"container-title":["IEEE Transactions on Visualization and Computer Graphics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/2945\/8653248\/08326724.pdf?arnumber=8326724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T21:14:19Z","timestamp":1657746859000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/8326724\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,1]]},"references-count":51,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1109\/tvcg.2018.2818701","relation":{},"ISSN":["1077-2626","1941-0506","2160-9306"],"issn-type":[{"value":"1077-2626","type":"print"},{"value":"1941-0506","type":"electronic"},{"value":"2160-9306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,1]]}}}