{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T05:54:52Z","timestamp":1770530092534,"version":"3.49.0"},"reference-count":75,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"DOI":"10.13039\/100016394","name":"Ludwig Center at Harvard","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016394","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006691","name":"Harvard Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["NCI U2C-CA233262"],"award-info":[{"award-number":["NCI U2C-CA233262"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["NCI U2C-CA233280"],"award-info":[{"award-number":["NCI U2C-CA233280"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["NCI U54-CA225088"],"award-info":[{"award-number":["NCI U54-CA225088"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Trans. Visual. Comput. Graphics"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1109\/tvcg.2021.3114786","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T04:16:39Z","timestamp":1633407399000},"page":"259-269","source":"Crossref","is-referenced-by-count":19,"title":["Scope2Screen: Focus+Context Techniques for Pathology Tumor Assessment in Multivariate Image Data"],"prefix":"10.1109","volume":"28","author":[{"given":"Jared","family":"Jessup","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Krueger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Warchol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Hoffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Muhlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecily C.","family":"Ritch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Gaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Coy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-An","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Ren","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Santagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter K.","family":"Sorger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanspeter","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2764"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1145\/3234506"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1109\/INFVIS.2003.1249004"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1109\/IV.2008.18"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1145\/22949.22950"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80028-4"},{"key":"ref38","year":"21","journal-title":"labsyspharm\/s3segmenter - segmentation of cells from probability maps - https \/\/hub docker com\/r\/labsyspharm\/s3segmenter"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1145\/2470654.2481417"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2019.2934547"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2009.2035616"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2011.231"},{"key":"ref30","year":"0","journal-title":"HALO - image analysis platform for quantitative tissue analysis in digital pathology"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1917-7"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.31657"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1002\/cpch.14"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2019.2934555"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2012.213"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.4470554"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1145\/1240624.1240777"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2020.3030336"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.21105\/joss.02579"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1109\/ISBI.2011.5872394"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1145\/642611.642648"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107523"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007313"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2011.223"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1080\/10520290500138372"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.2312\/EUROVISSTAR.20141172"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1111\/cgf.12871"},{"key":"ref2","year":"0","journal-title":"The OME-TIFF format — OME Data Model and File Formats 5 6 3 documentation"},{"key":"ref1","year":"0","journal-title":"Lensing an npm package"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1145\/1456650.1456652"},{"key":"ref22","article-title":"Ball*-tree: Efficient spatial indexing for constrained nearest-neighbor search in metric spaces","author":"dolatshah","year":"2015","journal-title":"arXiv 1511 00628 [cs]"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2016.2598587"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.31219\/osf.io\/wd2gu"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2011.243"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.010"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300136110"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-61864-3_29"},{"key":"ref51","author":"nirmal","year":"0","journal-title":"Scimap-Single-Cell Image Analysis Package"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01308-y"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nmeth.4391","article-title":"histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data","volume":"14","author":"schapiro","year":"2017","journal-title":"Nature Methods"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.patter.2020.100120"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.053"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1101\/2020.03.27.001834"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1109\/CVPR.2005.188"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1109\/TIP.2007.902329"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2020.153040"},{"key":"ref10","first-page":"33","article-title":"Pyramid methods in image processing","volume":"29","author":"adelson","year":"1984","journal-title":"RCA Engineer"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2016.06.037"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1896"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1109\/HICSS.2011.339"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17204-5"},{"key":"ref14","first-page":"8","author":"bier","year":"0","journal-title":"Toolglass and Magic Lenses The See-Through Interface"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2020.2986331"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0508-1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1109\/38.595268"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-70956-5_2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-47483-6_5"},{"key":"ref4","year":"0","journal-title":"Scope2screen codebase"},{"key":"ref3","year":"0","journal-title":"OpenSeadragon - An open-source web-based viewer for high-resolution zoomable images"},{"key":"ref6","year":"0","journal-title":"Visiopharm TissueAlign - high-quality alignment of serial sections"},{"key":"ref5","year":"0","journal-title":"Sliding window histogram skimage image processing in python v0 18 0 docs"},{"key":"ref8","year":"0","journal-title":"Webgl 2 0 specification"},{"key":"ref49","author":"muhlich","year":"2021","journal-title":"Ashlar - alignment by simultaneous harmonization of layer\/adjacency registration"},{"key":"ref7","year":"0","journal-title":"Visiopharm Viewer - AI-driven Pathology software"},{"key":"ref9","year":"0","journal-title":"Zarr — zarr 2 6 1 documentation"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1111\/cgf.12406"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.3773450"},{"key":"ref48","article-title":"Stitching and registering highly multiplexed whole slide images of tissues and tumors using ashlar software","author":"muhlich","year":"2021","journal-title":"BioRxiv"},{"key":"ref47","author":"molin","year":"2016","journal-title":"Diagnostic Review with Digital Pathology"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1109\/CVPRW.2016.78"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.31219\/osf.io\/wd2gu"},{"key":"ref44","year":"2021","journal-title":"(Silverlight) Deep Zoom File Format Overview"},{"key":"ref43","first-page":"14","author":"miao","year":"0","journal-title":"Quick Annotator an open-source digital pathology based rapid image annotation tool"}],"container-title":["IEEE Transactions on Visualization and Computer Graphics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/2945\/9663056\/09557792.pdf?arnumber=9557792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T17:57:02Z","timestamp":1649440622000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/9557792\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":75,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1109\/tvcg.2021.3114786","relation":{},"ISSN":["1077-2626","1941-0506","2160-9306"],"issn-type":[{"value":"1077-2626","type":"print"},{"value":"1941-0506","type":"electronic"},{"value":"2160-9306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}