{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:14:17Z","timestamp":1778055257767,"version":"3.51.4"},"reference-count":36,"publisher":"IEEE","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1109\/wsc.2007.4419683","type":"proceedings-article","created":{"date-parts":[[2008,1,4]],"date-time":"2008-01-04T21:05:18Z","timestamp":1199480718000},"page":"871-880","source":"Crossref","is-referenced-by-count":21,"title":["Combining micro and macro-modeling in DEVS for computational biology"],"prefix":"10.1109","author":[{"given":"Adelinde M.","family":"Uhrmacher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Ewald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Maus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Jeschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Biermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1109\/WSC.2006.323165"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1080\/08839519508945472"},{"key":"ref31","article-title":"Multi-Level Discrete-Event Modeling in Systems Biology","author":"uhrmacher","year":"2004","journal-title":"Computational Methods in Systems Biology"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1109\/AIHAS.1993.410588"},{"key":"ref36","article-title":"Theory of Modeling and Simulation","author":"zeigler","year":"2000"},{"key":"ref35","first-page":"164","article-title":"Concurrency in communicating object petri nets","author":"valk","year":"2001","journal-title":"Springer-Verlag New York Inc"},{"key":"ref34","article-title":"Multi-level modeling in systems biology by discrete event approaches","author":"uhrmacher","year":"2006","journal-title":"IT Themenheft Systems Biology"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1057\/palgrave.jos.4250018"},{"key":"ref11","first-page":"1","article-title":"Object Oriented and Hybrid Modeling in Modelica","volume":"35","author":"elmqvist","year":"2001","journal-title":"Journal Européen des Systèmes Automatisés"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1145\/132277.132280"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0167-6423(87)90035-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1021\/j100540a008"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20021051"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1109\/PADS.2004.1301292"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1093\/bioinformatics\/btl485","article-title":"COPA-SIa COmplex PAthway SImulator","volume":"22","author":"stefan","year":"2006","journal-title":"Bioinformatics"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/0037549705052227"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1126\/science.1069492","article-title":"Systems biology: a brief overview","volume":"295","author":"kitano","year":"2002","journal-title":"Science"},{"key":"ref28","doi-asserted-by":"crossref","DOI":"10.7312\/salt91068","author":"salthe","year":"1985","journal-title":"Evolving Hierarchical Systems"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0004-3702(97)00050-7"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/11567752"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1145\/268403.268423"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/978-1-349-01892-5_11","article-title":"Downward causation’ in hierarchically organised biological systems","author":"campbell","year":"1974","journal-title":"Studies in the Philosophy of Biology Reduction and related problems"},{"key":"ref29","first-page":"133","article-title":"The Micro Macro Link in DAI and Sociology","author":"schillo","year":"2001","journal-title":"MABS '00 Proceedings of the Second International Workshop on Multi-Agent-Based Simulation-Revised and Additional Papers"},{"key":"ref5","article-title":"Modelling the influence of RKIP on the ERK signalling pathway using the stochastic process algebra PEPA","author":"calder","year":"2004","journal-title":"Proceedings of the BioConcur Workshop on Concurrent Models in Molecular Biology"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1089\/10665270252833208"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb912"},{"key":"ref2","first-page":"6","article-title":"Modular Specification of Hybrid Systems in CHARON","author":"alur","year":"2000","journal-title":"Springer-Verlag"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biosystems.2004.03.008"},{"key":"ref1","article-title":"The Micro Macro Link","author":"alexander","year":"1987"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/19.2.261"},{"key":"ref22","article-title":"Modelling social behaviour with Petri net based multi-agent systems","author":"k\u00f6hler","year":"2003","journal-title":"Proceedings of the Workshop MASHO'03 at the KI 2003"},{"key":"ref21","article-title":"Advances in Social Theory and Methodology – Towards an Integration of Micro and Macro Sociologies","author":"knorr-cetina","year":"1981","journal-title":"Boston Routledge and Kegan Paul"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1177\/875647930600300405"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/17.6.575"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093\/comjnl\/38.7.578"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1109\/WSC.1998.745012"}],"event":{"name":"2007 Winter Simulation Conference","location":"Washington, DC, USA","start":{"date-parts":[[2007,12,9]]},"end":{"date-parts":[[2007,12,12]]}},"container-title":["2007 Winter Simulation Conference"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx5\/4419575\/4419576\/04419683.pdf?arnumber=4419683","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T15:00:52Z","timestamp":1557154852000},"score":1,"resource":{"primary":{"URL":"http:\/\/ieeexplore.ieee.org\/document\/4419683\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":36,"URL":"https:\/\/doi.org\/10.1109\/wsc.2007.4419683","relation":{},"subject":[],"published":{"date-parts":[[2007,12]]}}}