{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T16:28:44Z","timestamp":1743265724887,"version":"3.28.0"},"reference-count":61,"publisher":"IEEE","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1109\/wsc.2014.7019887","type":"proceedings-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T15:30:56Z","timestamp":1422372656000},"page":"177-191","source":"Crossref","is-referenced-by-count":3,"title":["Multi-level modeling and simulation of cell biological systems with ML-Rules - A tutorial"],"prefix":"10.1109","author":[{"given":"Tobias","family":"Helms","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Maus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiete","family":"Haack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelinde M.","family":"Uhrmacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1109\/WSC.2013.6721522"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1023\/A:1009600530279"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-5-166"},{"journal-title":"Toward Accessible Multilevel Modeling in Systems Biology A Rule-based Language Concept Logos Berlin","year":"2013","author":"maus","key":"ref32"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1063\/1.2771548"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-4-92"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ic.2005.07.003"},{"key":"ref36","first-page":"932","article-title":"Integrating Diverse Reaction Types into Stochastic Models - A Signaling Pathway Case Study in the Imperative pi-Calculus","author":"john","year":"2009","journal-title":"Proceedings of the 2009 Winter Simulation Conference"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"42792e","DOI":"10.1371\/journal.pone.0042792","article-title":"Elucidating the Sources of ß-Catenin Dynamics in Human Neural Progenitor Cells","volume":"7","author":"john","year":"2012","journal-title":"PLoS ONE"},{"key":"ref34","first-page":"515","article-title":"Quantitative and kinetic profile of Wnt\/ß-catenin signaling components during human neural progenitor cell differentiation","volume":"16","author":"hubner","year":"2011","journal-title":"Cellular & Molecular Biology Letters"},{"key":"ref60","article-title":"Computer Simulations in Science","author":"winsberg","year":"2013","journal-title":"The Stanford Encyclopedia of Philosophy"},{"journal-title":"Theory of Modeling and Simulation","year":"2000","author":"zeigler","key":"ref61"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp642"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-19718-5_18"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00133-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth378"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1272"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1109\/WSC.2012.6465073"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1109\/ANSS.2007.34"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-40708-6_3"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl485"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003544"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcp.2010.12.030"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/npre.2010.4959.1"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1109\/WSC.2009.5429309"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.18564\/jasss.2327"},{"key":"ref59","doi-asserted-by":"crossref","DOI":"10.1201\/b11812","author":"wilkinson","year":"2011","journal-title":"Stochastic Modelling for Systems Biology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1145\/352029.352035","article-title":"Domain-Specific Languages: An Annotated Bibliography","volume":"35","author":"van","year":"2000","journal-title":"SIGPlan Notices"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1109\/WSC.2007.4419683"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1063\/1.1810475"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1109\/PADS.2009.14"},{"journal-title":"Reinforcement Learning An Introduction","year":"1998","author":"sutton","key":"ref54"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1109\/WSC.2006.322933"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1546"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1145\/2001269.2001289"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1021\/j100540a008"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1145\/348.318586"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1063\/1.1378322"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1063\/1.4801941"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0167-6423(87)90035-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1063\/1.2354085"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1109\/WSC.2009.5429719"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-21834-7_2"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-68894-5_7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1145\/2486092.2486095"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cma.2008.02.024"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1063\/1.1824902"},{"key":"ref6","article-title":"Nested stochastic simulation algorithm for chemical kinetic systems with disparate rates","volume":"123","author":"liu","year":"2005","journal-title":"The Journal of Chemical Physics"},{"key":"ref5","first-page":"116","article-title":"Rule-Based Modelling and Model Perturbation","volume":"5750","author":"danos","year":"2009","journal-title":"Trans Comput Syst Biol X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-9-68"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1145\/2567895"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.4108\/icst.simutools.2014.254650"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-59745-525-1_5","article-title":"Rule-Based Modeling of Biochemical Systems with BioNetGen","volume":"500","author":"faeder","year":"2009","journal-title":"Systems Biology"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.4108\/ICST.SIMUTOOLS2010.8729"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp581"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq050"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1109\/WSC.2008.4736160"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1109\/35.978060"},{"journal-title":"Programming in Scala","year":"2008","author":"noble","key":"ref41"},{"key":"ref44","article-title":"Towards Composing ML-Rules Models","author":"peng","year":"2013","journal-title":"Proceedings of the 2013 Winter Simulation Conference"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1145\/2601381.2601394"}],"event":{"name":"2014 Winter Simulation Conference - (WSC 2014)","start":{"date-parts":[[2014,12,7]]},"location":"Savanah, GA, USA","end":{"date-parts":[[2014,12,10]]}},"container-title":["Proceedings of the Winter Simulation Conference 2014"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/7002492\/7019868\/07019887.pdf?arnumber=7019887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T18:55:44Z","timestamp":1651085744000},"score":1,"resource":{"primary":{"URL":"http:\/\/ieeexplore.ieee.org\/document\/7019887\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":61,"URL":"https:\/\/doi.org\/10.1109\/wsc.2014.7019887","relation":{},"subject":[],"published":{"date-parts":[[2014,12]]}}}