{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:10:12Z","timestamp":1788811812850,"version":"build-2803163510"},"reference-count":59,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFA1104800"],"award-info":[{"award-number":["2022YFA1104800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Gusu Leading Talent Entrepreneurship and Innovation Program","award":["ZXL2024349"],"award-info":[{"award-number":["ZXL2024349"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE J. Biomed. Health Inform."],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1109\/jbhi.2026.3668206","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:57:36Z","timestamp":1772053056000},"page":"7614-7625","source":"Crossref","is-referenced-by-count":0,"title":["mTIPs: Multimodal Time-Series Imaging and Prediction System for Early Differentiation of Retinal Organoids"],"prefix":"10.1109","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8350-4668","authenticated-orcid":false,"given":"Yi","family":"Wang","sequence":"first","affiliation":[{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-0389","authenticated-orcid":false,"given":"Yilin","family":"Qiao","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5693-5757","authenticated-orcid":false,"given":"Junao","family":"Song","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-zhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Ji Hua Laboratory","place":["Foshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1065-0034","authenticated-orcid":false,"given":"Min","family":"Ye","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5437-7749","authenticated-orcid":false,"given":"Jianbo","family":"Mao","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial People\u2019s Hospital (Affiliated People\u2019s Hospital, Hangzhou Medical College)","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2486-5677","authenticated-orcid":false,"given":"Ronald X.","family":"Xu","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0522-5511","authenticated-orcid":false,"given":"Mingzhai","family":"Sun","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2013.12.004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2021.101029"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61376-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2023.11.004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4114"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5047"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1324212111"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7286"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.104258"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24507"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI173892"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-023-10661-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.607341"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04543-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.104490"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1010584"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1039\/D2LC00596D"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-89409-y"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1109\/ACCESS.2025.3558621"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48874-y"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bosn.2025.01.002"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00171"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055082"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093952"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2019.0571"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.02.004"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22758-0"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1329840"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.23876\/j.krcp.22.017"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-023-00563-8"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-024-03483-3"},{"issue":"9","key":"ref32","first-page":"3311","article-title":"Structural and functional characterization of human stem-cell-derived retinal organoids by live imaging","volume":"58","author":"Browne","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1242\/dev.171686"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/s41377-020-00375-8"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2020.3038466"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.428197"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2022.114136"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.515781"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14121217"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1133090"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3791\/66246"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.429"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24574-4_28"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1109\/CVPR.2016.90"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1109\/ICCV.2019.00565"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46506-2"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2022.101093"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2012.05.009"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.3390\/cells9102270"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031444"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05378-w"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10061458"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmps.2019.103745"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-025-02685-4"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.10.006"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72828-4"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.01.020"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.63.10.12"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2024.3391215"}],"container-title":["IEEE Journal of Biomedical and Health Informatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/6221020\/11679032\/11411936.pdf?arnumber=11411936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:18:28Z","timestamp":1788808708000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11411936\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":59,"journal-issue":{"issue":"9"},"URL":"https:\/\/doi.org\/10.1109\/jbhi.2026.3668206","relation":{},"ISSN":["2168-2208","2168-2194"],"issn-type":[{"value":"2168-2208","type":"electronic"},{"value":"2168-2194","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]}}}