{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:11:45Z","timestamp":1793913105560,"version":"4.8.0"},"reference-count":55,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2024YFE0102100"],"award-info":[{"award-number":["2024YFE0102100"]}]},{"name":"2022 Hainan Provincial Health Commission General Research Project","award":["22A200345"],"award-info":[{"award-number":["22A200345"]}],"id":[{"id":"https:\/\/ror.org\/04nm1xm49","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds for the Central Universities"},{"name":"DHU Distinguished Young Professor Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE J. Biomed. Health Inform."],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1109\/jbhi.2026.3678339","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T20:07:33Z","timestamp":1774901253000},"page":"8659-8671","source":"Crossref","is-referenced-by-count":1,"title":["MPAExpo-LM: Fine-Tuned Large Language Model for Mycophenolic Acid Exposure Estimation After Renal Transplantation"],"prefix":"10.1109","volume":"30","author":[{"given":"Dehua","family":"Chen","sequence":"first","affiliation":[{"name":"Donghua University","place":["Shanghai, China"],"department":["Department of the School of Information and Intelligent Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8427-217X","authenticated-orcid":false,"given":"Huilin","family":"Liu","sequence":"additional","affiliation":[{"name":"Donghua University","place":["Shanghai, China"],"department":["Department of the School of Information and Intelligent Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Ge","sequence":"additional","affiliation":[{"name":"Donghua University","place":["Shanghai, China"],"department":["Department of the School of Information and Intelligent Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zuo","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of medicine","place":["Shanghai, China"],"department":["Information Center, Ruijin Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"An","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of medicine","place":["Shanghai, China"],"department":["Department of Urology and Transplant Surgery, Ruijin Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of medicine","place":["Shanghai, China"],"department":["Department of Urology and Transplant Surgery, Ruijin Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangxi","family":"Fu","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of medicine","place":["Shanghai, China"],"department":["Department of Urology and Transplant Surgery, Ruijin Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of medicine","place":["Shanghai, China"],"department":["Department of Urology and Transplant Surgery, Ruijin Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghui","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of medicine","place":["Shanghai, China"],"department":["Department of Urology and Transplant Surgery, Ruijin Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of medicine","place":["Shanghai, China"],"department":["Department of Clinical Pharmacology, Ruijin Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4545-3476","authenticated-orcid":false,"given":"Kun","family":"Shao","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of medicine","place":["Shanghai, China"],"department":["Department of Urology and Transplant Surgery, Ruijin Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1191\/0961203305lu2109oa"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14124"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200746010-00002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199907270-00018"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01983.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02668.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1517\/17425250903114182"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-023-09892-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/48.9.1497"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.12.027"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200746050-00002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2165\/11318060-000000000-00000"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq819"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000351180"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000165"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5414\/cp202583"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.70056"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1352"},{"key":"ref19","first-page":"117","article-title":"Postoperative MPA-AUC prediction for kidney transplant recipients based on model interpretability technique","volume-title":"Proc. 3rd Int. Conf. Big Data Eng.","author":"Qiao"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2216"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1109\/caibda53561.2021.00056"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1109\/SWC50871.2021.00035"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000001020"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-023-07154-0"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.2156"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.engappai.2024.109561"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.52202\/079017-2522"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1145\/3458754"},{"key":"ref29","article-title":"Evaluating LLMgenerated multimodal diagnosis from medical images and symptom analysis","author":"Panagoulias","year":"2024"},{"issue":"3","key":"ref30","first-page":"48","article-title":"AI-Driven PKPD modeling: Generative AI, LLMs, and LangChain for precision medicine","volume":"1","author":"Ray","year":"2025","journal-title":"Compassionate AI"},{"key":"ref31","article-title":"How to evaluate reward models for RLHF","author":"Frick","year":"2024"},{"issue":"8","key":"ref32","first-page":"9","article-title":"Language models are unsupervised multitask learners","volume":"1","author":"Radford","year":"2019","journal-title":"OpenAI Blog"},{"key":"ref33","article-title":"Differential transformer","volume-title":"Proc. 13th Int. Conf. Learn. Representations","author":"Ye","year":"2025"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.15471"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12810"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1145\/3422622"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.52202\/068431-2011"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-3109(00)00188-0"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1D063"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1097\/ftd.0000000000000871"},{"key":"ref41","article-title":"Deepseek llm: Scaling open-source language models with longtermism","author":"Bi","year":"2024"},{"key":"ref42","article-title":"Qwen technical report","author":"Bai","year":"2023"},{"key":"ref43","article-title":"Llama: Open and efficient foundation language models","author":"Touvron","year":"2023"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/0098-3004(93)90090-R"},{"key":"ref45","first-page":"2579","article-title":"Visualizing data using t-SNE","volume":"9","author":"Maaten","year":"2008","journal-title":"J. Mach. Learn. Res."},{"key":"ref46","first-page":"6840","article-title":"Denoising diffusion probabilistic models","volume":"33","author":"Jonathan","year":"2020","journal-title":"Adv. Neural Inf. Process. Syst."},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.3233\/JIFS-221902"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.18280\/ria.370229"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1007\/s10462-024-10884-2"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2010.06.008"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12495"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.2174\/1389200224666230124121304"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-025-02142-6"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-022-01121-1"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.13488"}],"container-title":["IEEE Journal of Biomedical and Health Informatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx8\/6221020\/11720547\/11457323.pdf?arnumber=11457323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:13:26Z","timestamp":1791314006000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/11457323\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":55,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.1109\/jbhi.2026.3678339","relation":{},"ISSN":["2168-2208","2168-2194"],"issn-type":[{"value":"2168-2208","type":"electronic"},{"value":"2168-2194","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]}}}