{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:01:20Z","timestamp":1792022480304,"version":"4.4.0"},"reference-count":113,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/OAPA.html"}],"funder":[{"name":"French National Research Agency ANR, Project MICO, reference ANR-10-TECS-015"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Rev. Biomed. Eng."],"published-print":{"date-parts":[[2014]]},"DOI":"10.1109\/rbme.2013.2295804","type":"journal-article","created":{"date-parts":[[2014,1,31]],"date-time":"2014-01-31T17:52:25Z","timestamp":1391190745000},"page":"97-114","source":"Crossref","is-referenced-by-count":579,"title":["Methods for Nuclei Detection, Segmentation, and Classification in Digital Histopathology: A Review\u2014Current Status and Future Potential"],"prefix":"10.1109","volume":"7","author":[{"given":"Humayun","family":"Irshad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Veillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Roux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Racoceanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"263","reference":[{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2010.2041232"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2010.2055058"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1109\/ISBI.2011.5872483"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2009.2035102"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.patcog.2008.10.029"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1109\/IEMBS.2009.5332910"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2010.2060486"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2010.2060336"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-85988-8_99"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1109\/ICPR.2008.4761744"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1977.tb01600.x"},{"key":"ref45","first-page":"281","article-title":"Some methods for classification and analysis of multivariate observations","volume":"1","author":"macqueen","year":"1967","journal-title":"Proc 5th Berkeley Symp Math Statist Probabil"},{"key":"ref48","first-page":"731","article-title":"Normalized cuts and image segmentation","author":"shi","year":"1997","journal-title":"Proc IEEE Comput Soc Conf Comput Vis Pattern Recog"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.2002.1023800"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.3233\/FI-2000-411207"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/S0146-664X(76)80014-7"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1109\/4233.992158"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1007\/BF00133570"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1109\/ICPR.2008.4761112"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/1361-6374(199806)6:2<79::AID-BIO3>3.3.CO;2-R"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1109\/10.536902"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1109\/IEMBS.2006.260837"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1109\/MSP.2006.1628879"},{"key":"ref3","author":"rubin","year":"2004","journal-title":"Rubin's Pathology Clinicopathologic Foundations of Medicine"},{"key":"ref6","first-page":"459","article-title":"Bayesian belief networks in quantitative histopathology","volume":"14","author":"bartels","year":"1992","journal-title":"Anal Quant Cytol Histol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1109\/RBME.2009.2034865"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1109\/TIP.2002.800889"},{"key":"ref101","year":"0"},{"key":"ref40","article-title":"Mathematical morphology: Basic principles","author":"heijmans","year":"1995","journal-title":"Proc Summer School Morphological Image Signal Process"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007\/BF01834640"},{"key":"ref34","article-title":"Pathological prognostic factors in breast cancer. the value of histological grade in breast cancer experience from a large study with long-term follow-up","volume":"41 pp 151?153","author":"elston","year":"2002","journal-title":"Histopathology"},{"key":"ref37","first-page":"349","article-title":"An automatic threshold selection method based on discriminate and least squares criteria","volume":"63","author":"otsu","year":"1979","journal-title":"Denshi Tsushin Gakkai Ronbunshi"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01220.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.1.38"},{"key":"ref30","first-page":"271","article-title":"Computer assisted diagnosis in histopathology","author":"he","year":"2010","journal-title":"Sequence Genome Anal Methods Appl"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-0539"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-33415-3_45"},{"key":"ref39","author":"serra","year":"1983","journal-title":"Image Analysis and Mathematical Morphology"},{"key":"ref38","article-title":"Adaptive thresholding for the digital desk","author":"wellner","year":"1993","journal-title":"Xerox EPC1993-110"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.patcog.2009.10.014"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1117\/12.769802"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-2720.2004.01338.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2010.02.002"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.compmedimag.2010.11.009"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH708>3.0.CO;2-I"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.patcog.2012.01.021"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-23623-5_83"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4103\/2153-3539.92030"},{"key":"ref29","article-title":"Automated cancer diagnosis based on histopathological images: A systematic survey","author":"demir","year":"2005","journal-title":"Dept Comput Sci Rensselaer Polytechnic Inst Troy NY USA Tech Rep TR-05-09"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10182"},{"key":"ref12","first-page":"861","article-title":"Nuclear feature extraction for breast tumor diagnosis","volume":"1905","author":"street","year":"1993","journal-title":"Proc Int Symp Electron Imag Sci Technol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2342-6-14"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth933"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-40763-5_51"},{"key":"ref96","article-title":"Mitosis detection in breast cancer histological images an ICPR 2012 contest","volume":"4 pp 8?14","author":"roux","year":"2013","journal-title":"J Pathol Inform"},{"key":"ref11","first-page":"6605","article-title":"Towards building computerized image analysis framework for nucleus discrimination in microscopy images of diffuse glioma","author":"kong","year":"2011","journal-title":"Proc IEEE 33rd Annu Int Conf Eng Med Biol Soc"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1109\/ICPR.2008.4761451"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.patcog.2010.01.005"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1109\/EMBC.2013.6610942"},{"key":"ref17","article-title":"Nuclear pleomorphism scoring by selective cell nuclei detection","author":"dalle","year":"2009","journal-title":"Proc IEEE Workshop Appl Comput Vis"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1109\/BMEI.2008.166"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2011.2110648"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2009.2035305"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1109\/TPAMI.2003.1217601"},{"key":"ref92","author":"gonzalez","year":"2008","journal-title":"Digital Image Processing"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1016\/j.compmedimag.2011.02.006"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1109\/TIP.2007.891154"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199705)182:1<68::AID-PATH811>3.3.CO;2-E"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3203(98)00122-8"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.4103\/2153-3539.112695"},{"key":"ref86","article-title":"A Gamma&#x2013;Gaussian mixture model for detection on mitotic cells in breast histology images","author":"khan","year":"2012","journal-title":"Proc 21th Int Conf Pattern Recog"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-15948-0_8"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1109\/IranianMVIP.2010.5941151"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1109\/TITB.2005.847515"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1109\/38.946629"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1109\/ISBI.2011.5872492"},{"key":"ref84","first-page":"291","article-title":"Quantification of histochemical staining by color deconvolution.","volume":"23","author":"ruifrok","year":"2001","journal-title":"Anal Quant Cytol Histol \/Int Acad Cytol Amer Soc Cytol"},{"key":"ref83","first-page":"1","article-title":"Context aware colour classification in digital microscopy","author":"magee","year":"2010","journal-title":"Proc Med Image Understand Anal"},{"key":"ref80","first-page":"1107","article-title":"A method for normalizing histology slides for quantitative analysis","author":"macenko","year":"2011","journal-title":"Proc IEEE Int Symp Biomed Imag Nano Macro"},{"key":"ref79","first-page":"100","article-title":"Colour normalisation in digital histopathology images","author":"magee","year":"2009","journal-title":"Proc Opt Tissue Image Anal Microsc Histopathol Endosc"},{"key":"ref108","article-title":"Object and spatial-level quantitative analysis of multispectral histopathology images for detection and characterization of cancer","author":"boucheron","year":"2008","journal-title":"Dept of Electrical and Computer Eng"},{"key":"ref78","article-title":"Transillumination method apparatus for the diagnosis of breast tumors and other breast lesions by normalization of an electronic image of the breast","author":"grenier","year":"1992","journal-title":"U S Patent 5\ufffd079\ufffd698"},{"key":"ref109","first-page":"6601","article-title":"Features for cells and nuclei classification","author":"liu","year":"2011","journal-title":"Proc IEEE 33rd Annu Int Conf Eng Med Biol Soc"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1016\/j.patcog.2007.11.006"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.1155\/2003\/548678"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1109\/CIBCB.2011.5948457"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1109\/83.902291"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.8.619"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1109\/TVCG.2008.30"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1109\/ISBI.2008.4540989"},{"key":"ref102","first-page":"5445","article-title":"Segmenting overalapping cell nuclei in digital histopathology images","author":"shu","year":"2013","journal-title":"Proc IEEE 35th Annu Int Conf Eng Med Biol Soc"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2012.03645.x"},{"key":"ref103","year":"0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0510-74"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20003"},{"key":"ref71","year":"0"},{"key":"ref111","first-page":"1","article-title":"A biosegmentation benchmark for evaluation of bioimage analysis methods","volume":"10","author":"gelasca","year":"2009","journal-title":"BMC Bioinform"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.4103\/2153-3539.109802"},{"key":"ref112","year":"0"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.2144\/000112488"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.4103\/2153-3539.112694"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.4103\/2153-3539.109870"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1038\/srep00503"},{"key":"ref67","article-title":"Cell nuclei extraction from breast cancer histopathology images using color, texture, scale and shape information","author":"veillard","year":"2012","journal-title":"Proc 11th Eur Congr Telepathol 5th Int Congr Virt Microsc"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1111\/jmi.12001"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1109\/TBME.2011.2179298","article-title":"Robust segmentation of overlapping cells in histopathology specimens using parallel seed detection and repulsive level set","volume":"59","author":"qi","year":"2012","journal-title":"IEEE Trans Biomed Eng"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2012.2190089"},{"key":"ref66","first-page":"614","article-title":"Nuclear segmentation in H&E sections via multi-reference graph cut (MRGC)","author":"chang","year":"2012","journal-title":"Proc 9th IEEE Int Symp Biomed Imag Nano Macro"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/385271"},{"key":"ref65","year":"0"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2011.2141674"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.compmedimag.2011.02.005"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1109\/CCCA.2011.6031229"}],"container-title":["IEEE Reviews in Biomedical Engineering"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/4664312\/6805676\/06690201.pdf?arnumber=6690201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T22:27:25Z","timestamp":1683066445000},"score":1,"resource":{"primary":{"URL":"http:\/\/ieeexplore.ieee.org\/document\/6690201\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":113,"URL":"https:\/\/doi.org\/10.1109\/rbme.2013.2295804","relation":{},"ISSN":["1937-3333","1941-1189"],"issn-type":[{"value":"1937-3333","type":"print"},{"value":"1941-1189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}