{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T09:11:47Z","timestamp":1774948307452,"version":"3.50.1"},"reference-count":70,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/ieeexplore.ieee.org\/Xplorehelp\/downloads\/license-information\/IEEE.html"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"}],"funder":[{"name":"National Institute of Health","award":["11675980"],"award-info":[{"award-number":["11675980"]}]},{"name":"American Heart Association Scientist Development","award":["17SDG33670677"],"award-info":[{"award-number":["17SDG33670677"]}]},{"name":"The University of Alabama at Birmingham Comprehensive Cardiovascular Center and Department of Biomedical Engineering"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32HL007918-18"],"award-info":[{"award-number":["5T32HL007918-18"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"American Heart Association Scientist Development","award":["17SDG33670677"],"award-info":[{"award-number":["17SDG33670677"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE Trans. Biomed. Eng."],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1109\/tbme.2019.2905763","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T23:40:42Z","timestamp":1552952442000},"page":"3436-3443","source":"Crossref","is-referenced-by-count":38,"title":["Cardiac Tissue Chips (CTCs) for Modeling Cardiovascular Disease"],"prefix":"10.1109","volume":"66","author":[{"given":"Aaron J.","family":"Rogers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramaswamy","family":"Kannappan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5794-2037","authenticated-orcid":false,"given":"Palaniappan","family":"Sethu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"263","reference":[{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2012.10.011"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112891"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.02.097"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.12.001"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s11626-010-9368-1"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2016.04.016"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12064"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129303"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.69.6.1487"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.69.6.1476"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmu046"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00027.2017"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.19.2402"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2003.10.010"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000254415.31362.a7"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1177\/1753944714527490"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(96)00140-4"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.012975"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2005.068270"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200524408"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e318224ab93"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv305"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-12-158"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.2174\/1570161054368607"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/jfb7010001"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/1087057115594589"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3109\/15376516.2012.666650"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2006.02336.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(89)90778-5"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.465"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.01.013"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0000000000000255"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.03.019"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2003.11.014"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1992.262.6.H1861"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.8.846"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2015.11.3518"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.01.004"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1999.1037"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016138813353"},{"key":"ref54","first-page":"1915","article-title":"Cyclic stretching force selectively up-regulates transforming growth factor-beta isoforms in cultured rat mesangial cells","volume":"148","author":"riser","year":"1996","journal-title":"Amer J Pathol"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.21.2750"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.9.2385"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.12.011"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0016-3"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1039\/c2lc40663b"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1021\/ac503716z"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1021\/ac401910d"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b03105"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.17-565"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/5.10.758"},{"key":"ref17","first-page":"iv66","article-title":"Heart failure on the basis of hypertension","volume":"87","author":"schwartzkopff","year":"1993","journal-title":"Circulation"},{"key":"ref18","first-page":"99","article-title":"Remodeling of the heart in chronic pressure overload","volume":"86","author":"swynghedauw","year":"1991","journal-title":"Basic Res Cardiol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq308"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2015.0482"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b11671"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311920"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.04.026"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.014998"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1424042112"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.122.1.103"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2018.03.016"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0457"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.10.033"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1136\/heart.89.10.1255"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00578.2001"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01946-x"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b03105"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026053530766"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1115\/1.4030668"}],"container-title":["IEEE Transactions on Biomedical Engineering"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/10\/8907481\/08668522.pdf?arnumber=8668522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T21:08:33Z","timestamp":1657746513000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/8668522\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":70,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.1109\/tbme.2019.2905763","relation":{},"ISSN":["0018-9294","1558-2531"],"issn-type":[{"value":"0018-9294","type":"print"},{"value":"1558-2531","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]}}}