{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T22:30:25Z","timestamp":1757457025694,"version":"3.37.3"},"reference-count":30,"publisher":"Institute of Electrical and Electronics Engineers (IEEE)","issue":"2","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/legalcode"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["097829"],"award-info":[{"award-number":["097829"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009150","name":"Centre for Chronic Diseases and Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009001","name":"University of York","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0601156"],"award-info":[{"award-number":["G0601156"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"EPSRC","doi-asserted-by":"publisher","award":["EP\/I005943\/1"],"award-info":[{"award-number":["EP\/I005943\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000287","name":"Royal Academy of Engineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000287","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006129","name":"FCT","doi-asserted-by":"publisher","award":["PTDC\/SAU-MII\/100016\/2008"],"award-info":[{"award-number":["PTDC\/SAU-MII\/100016\/2008"]}],"id":[{"id":"10.13039\/100006129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organisation","doi-asserted-by":"publisher","award":["1648"],"award-info":[{"award-number":["1648"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["207057"],"award-info":[{"award-number":["207057"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IEEE\/ACM Trans. Comput. Biol. and Bioinf."],"published-print":{"date-parts":[[2017,3,1]]},"DOI":"10.1109\/tcbb.2016.2527654","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T07:43:35Z","timestamp":1455176615000},"page":"431-442","source":"Crossref","is-referenced-by-count":4,"title":["Extending and Applying Spartan to Perform Temporal Sensitivity Analyses for Predicting Changes in Influential Biological Pathways in Computational Models"],"prefix":"10.1109","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4411-1776","authenticated-orcid":false,"given":"Kieran","family":"Alden","sequence":"first","affiliation":[]},{"given":"Jon","family":"Timmis","sequence":"additional","affiliation":[]},{"given":"Paul S.","family":"Andrews","sequence":"additional","affiliation":[]},{"given":"Henrique","family":"Veiga-Fernandes","sequence":"additional","affiliation":[]},{"given":"Mark","family":"Coles","sequence":"additional","affiliation":[]}],"member":"263","reference":[{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-77362-7_9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2014.1059"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2007.00499.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.11.6593"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/9.4.507"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.5.621"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021294"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030169"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1126\/science.286.5447.2098"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080\/13873954.2011.601419"},{"journal-title":"Sensitivity Analysis in Practice A Guide to Assessing Scientific Models","year":"2004","author":"saltelli","key":"ref19"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-9473(97)00043-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00172"},{"key":"ref27","first-page":"614","article-title":"Novel approaches to the visualization and quantification of biological simulations by emulating experimental techniques","author":"butler","year":"0","journal-title":"Proc 10th Int Conf Simul Synthesis Living Syst"},{"key":"ref3","article-title":"Differential RET responses orchestrate lymphoid and nervous enteric system development","volume":"5","author":"patel","year":"2012","journal-title":"Sci Signall"},{"key":"ref6","first-page":"1","article-title":"New insights into the development of lymphoid tissues","volume":"10","author":"pavert","year":"2010","journal-title":"Nature Rev Immunol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.2307\/1268522"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090257"},{"article-title":"The CoSMoS Process, Version 0.1 : A Process for the modelling and simulation of complex systems","year":"0","author":"andrews","key":"ref8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/nature05597"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.32614\/RJ-2014-025","article-title":"Applying spartan to understand parameter uncertainty in simulations","volume":"6","author":"alden","year":"2014","journal-title":"R Journal"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2014.0704"},{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1371\/annotation\/cfcaffb6-8515-4595-b6cc-85b84703d7d5"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jtbi.2008.04.011","article-title":"A methodology for performing global uncertainty and sensitivity analysis in systems biology","volume":"254","author":"marino","year":"2008","journal-title":"J Theor Biol"},{"journal-title":"J Immunol","year":"0","key":"ref22"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/ni1022"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000534"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2307\/1165329"},{"key":"ref26","first-page":"93","article-title":"Simulating biology: Towards understanding what the simulation shows","author":"andrews","year":"0","journal-title":"Proc Workshop Complex Syst Model Simul"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/11536444_17"}],"container-title":["IEEE\/ACM Transactions on Computational Biology and Bioinformatics"],"original-title":[],"link":[{"URL":"http:\/\/xplorestaging.ieee.org\/ielx7\/8857\/7887773\/07403919.pdf?arnumber=7403919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T11:41:59Z","timestamp":1641987719000},"score":1,"resource":{"primary":{"URL":"https:\/\/ieeexplore.ieee.org\/document\/7403919\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,1]]},"references-count":30,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1109\/tcbb.2016.2527654","relation":{},"ISSN":["1545-5963","1557-9964","2374-0043"],"issn-type":[{"type":"print","value":"1545-5963"},{"type":"electronic","value":"1557-9964"},{"type":"electronic","value":"2374-0043"}],"subject":[],"published":{"date-parts":[[2017,3,1]]}}}