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Sequence similarity searches reveal that the \u03b1\u2010subunit of protein prenyltransferases (PT\u03b1) is a member of the tetratricopeptide repeat (TPR) super\u2010family. This finding makes the three\u2010dimensional structure of the rat protein farnesyltransferase the first structural model of a TPR protein interacting with its protein partner. Structural comparison of the two TPR domains in protein farnesyltransferase and protein phosphatase 5 indicates that variation in TPR consensus residues may affect protein binding specificity through altering the overall shape of the TPR superhelix. A general approach to evolutionary analysis of proteins with repetitive sequence motifs has been developed and applied to the protein prenyltransferases and other TPR proteins. The results suggest that all members in PT\u03b1 family originated from a common multirepeat ancestor, while the common ancestor of PT\u03b1 and other members of TPR superfamily is likely to be a single repeat protein.<\/jats:p>","DOI":"10.1110\/ps.8.8.1658","type":"journal-article","created":{"date-parts":[[2009,2,17]],"date-time":"2009-02-17T19:58:25Z","timestamp":1234900705000},"page":"1658-1667","source":"Crossref","is-referenced-by-count":18,"title":["The \u03b1\u2010subunit of protein prenyltransferases is a member of the tetratricopeptide repeat family"],"prefix":"10.1002","volume":"8","author":[{"given":"Hong","family":"Zhang","sequence":"first","affiliation":[]},{"given":"Nick V","family":"Grishin","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2008,12,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(98)00091-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)54087-4"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"12221","DOI":"10.1016\/S0021-9258(19)50329-5","article-title":"cDNA cloning and expression of the alpha and beta subunits of rat Rab geranyl\u2010geranyl transferase","volume":"268","author":"Armstrong SA","year":"1993","journal-title":"J Biol Chem"},{"key":"e_1_2_1_6_1","first-page":"408","article-title":"Novel repetitive sequence motifs in the alpha and beta subunits of prenyl\u2010protein transferases and homology of the alpha subunit to the MAD2 gene product of yeast","volume":"4","author":"Boguski MS","year":"1992","journal-title":"New Biol"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.10.5289"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06748.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)98402-4"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(81)90341-7"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0365110X53001964"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.5.1192"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1093-3263(97)00021-1"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(96)66026-1"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.37.1.143"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(96)80180-0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.22.10915"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1993.1489"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(88)90606-7"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1998.1643"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(01)00222-2"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(94)90090-6"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-0280-1_14"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889891004399"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06752.x"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(00)89037-4"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi980708e"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.14.9316"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1948029"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5307.1800"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0898-6568(97)00120-4"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"14497","DOI":"10.1016\/S0021-9258(19)49740-8","article-title":"Rab geranylgeranyl transferase. 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