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These TCR \u03b2 chains form homo\u2010dimers in solution and in crystals. Structural comparison reveals that the main\u2010chain conformations in the CDR regions of the C5\u20131 and SF4 V\u03b217 closely resemble those of a V\u03b217 JM22 in a bound form; however, the CDR3 region shows different conformations among these three V\u03b217 structures. At the side\u2010chain level, conformational differences were observed at the CDR2 regions between our two ligand\u2010free forms and the bound JM22 form. Other significant differences were observed at the V\u03b2 regions 8\u201312, 40\u201344, and 82\u201388 between C5\u20131\/SF4 and JM22 V\u03b217, implying that there is considerable variability in the structures of very similar \u03b2 chains. Structural alignments also reveal a considerable variation in the V\u03b2\u2013C\u03b2 associations, and this may affect ligand recognition. The crystal structures also provide insights into the structure basis of T cell recognition of <jats:italic>Mycoplasma arthritidis<\/jats:italic> mitogen (MAM), a superantigen that may be implicated in the development of human RA. Structural comparisons of the V\u03b2 domains of known TCR structures indicate that there are significant similarities among V\u03b2 regions that are MAM\u2010reactive, whereas there appear to be significant structural differences among those V\u03b2 regions that lack MAM\u2010reactivity. It further reveals that CDR2 and framework region (FR) 3 are likely to account for the binding of TCR to MAM.<\/jats:p>","DOI":"10.1110\/ps.051748305","type":"journal-article","created":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T01:34:28Z","timestamp":1130808868000},"page":"3025-3038","source":"Crossref","is-referenced-by-count":10,"title":["Crystal structures of T cell receptor \u03b2 chains related to rheumatoid arthritis"],"prefix":"10.1002","volume":"14","author":[{"given":"Hongmin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Van Vranken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Eisele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.4.1387"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/7.8.1311"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3358"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-5890(02)00034-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.3.832"},{"key":"e_1_2_6_7_1","first-page":"373","article-title":"Serum IgG anti\u2010native type II collagen antibodies in rheumatoid arthritis: Association with HLA DR4 and lack of clinical correlation","volume":"6","author":"Banerjee S.","year":"1988","journal-title":"Clin. 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