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Comparison of the results with those previously obtained for the Parkinson's disease\u2010linked protein \u03b1\u2010synuclein shows that structural differences between the three homologous synuclein family members are directly related to variations in their primary amino acid sequences. An 11\u2010residue deletion in the lipid\u2010binding domain of \u03b2\u2010synuclein leads to the destabilization of an entire segment of the micelle\u2010bound helical structure containing the deletion site. The acidic C\u2010terminal tail region of \u03b3\u2010synuclein, which displays extensive sequence divergence, is more highly disordered than the corresponding regions in the other two family members. The observed structural differences are likely to mediate functional variations between the three proteins, with differences between \u03b1\u2010 and \u03b2\u2010synuclein expected to revolve around their lipid interactions, while differences in \u03b3\u2010synuclein function are expected to result from different protein\u2013protein interactions mediated by its unique C\u2010terminal tail.<\/jats:p>","DOI":"10.1110\/ps.051803606","type":"journal-article","created":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T13:56:38Z","timestamp":1144331798000},"page":"1162-1174","source":"Crossref","is-referenced-by-count":46,"title":["Secondary structure and dynamics of micelle bound \u03b2\u2010 and \u03b3\u2010synuclein"],"prefix":"10.1002","volume":"15","author":[{"given":"Yoon\u2010hui","family":"Sung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Eliezer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80886-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.36.21264"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi048448q"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(03)00601-X"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02913.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/416507a"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-22-09335.1998"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(03)00520-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi036135"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.041255905"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-20-08797.2002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M213128200"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406283101"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/3311"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.571"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.16.9443"},{"key":"e_1_2_8_18_1","first-page":"277","volume":"6","author":"Delaglio F.","year":"1995","journal-title":"NMRPipe: A multidimensional spectral processing system based on UNIX pipes. 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