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Domain III of the envelope protein (E\u2010D3) is considered to be the primary viral determinant involved in the virus\u2013host\u2010cell receptor interaction, and thus represents an excellent target for antiviral drug development. Langat (LGT) virus is a naturally attenuated BSL\u20102 TBE virus and is a model for the pathogenic BSL\u20103 and BSL\u20104 viruses in the serogroup. We have determined the solution structure of LGT\u2010E\u2010D3 using heteronuclear NMR spectroscopy. The backbone dynamics of LGT\u2010E\u2010D3 have been investigated using <jats:sup>15<\/jats:sup>N relaxation measurements. A detailed analysis of the solution structure and dynamics of LGT\u2010E\u2010D3 suggests potential residues that could form a surface for molecular recognition, and thereby represent a target site for antiviral therapeutics design.<\/jats:p>","DOI":"10.1110\/ps.051844006","type":"journal-article","created":{"date-parts":[[2006,5,27]],"date-time":"2006-05-27T00:18:54Z","timestamp":1148689134000},"page":"1342-1355","source":"Crossref","is-referenced-by-count":23,"title":["NMR solution structure and backbone dynamics of domain III of the E protein of tick\u2010borne Langat flavivirus suggests a potential site for molecular recognition"],"prefix":"10.1002","volume":"15","author":[{"given":"Munia","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaushik","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cowburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert O.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2144\/01306bm01"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.24.13097-13100.2002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.8.4002-4007.2001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600064"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4631"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00168a070"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1998.1419"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja9812610"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008392405740"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja9902221"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.16.7769-7773.2001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi034366a"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00197809"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2004.09.023"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi030268d"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00035a009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00185a040"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018670623695"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008349331773"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0771"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja981686m"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb1101-998"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(94)00090-Y"},{"key":"e_1_2_7_25_1","first-page":"379","article-title":"NOE assignment with ARIA 2.0: The nuts and bolts","volume":"278","author":"Habeck M.","year":"2004","journal-title":"Methods Mol. 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