{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:46:30Z","timestamp":1791294390579,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"vor","delay-in-days":1006,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Protein Science"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have determined the crystal structure of the DUF16 domain of unknown function encoded by the gene MPN010 of <jats:italic>Mycoplasma pneumoniae<\/jats:italic> at 1.8 \u00c5 resolution. The crystal structure revealed that this domain is composed of two separated homotrimeric coiled\u2010coils. The shorter one consists of 11 highly conserved residues. The sequence comprises noncanonical heptad repeats that induce a right\u2010handed coiled\u2010coil structure. The longer one is composed of approximately nine heptad repeats. In this coiled\u2010coil structure, there are three distinguishable regions that confer unique structural properties compared with other known homotrimeric coiled\u2010coils. The first part, containing one stutter, is an unusual phenylalanine\u2010rich region that is not found in any other coiled\u2010coil structures. The second part is a highly conserved glutamine\u2010rich region, frequently found in other trimeric coiled\u2010coil structures. The last part is composed of prototype heptad repeats. The phylogenetic analysis of the DUF16 family together with a secondary structure prediction shows that the DUF16 family can be classified into five subclasses according to N\u2010terminal sequences. Based on the structural comparison with other coiled\u2010coil structures, a probable molecular function of the DUF16 family is discussed.<\/jats:p>","DOI":"10.1110\/ps.051993506","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T02:43:27Z","timestamp":1141785807000},"page":"921-928","source":"Crossref","is-referenced-by-count":8,"title":["Crystal structure of the DUF16 domain of MPN010 from <i>Mycoplasma pneumoniae<\/i>"],"prefix":"10.1002","volume":"15","author":[{"given":"Dong 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