{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T14:09:07Z","timestamp":1775484547944,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":581,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Protein Science"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increasing evidence indicates that polypeptide aggregation often involves a nucleation and a growth phase, although the relationship between the factors that determine these two phases has not yet been fully clarified. We present here an analysis of several mutations at different sites of the A\u03b2(1\u201340) peptide, including those associated with early onset forms of the Alzheimer's disease, which reveals that the effects of specific amino acid substitutions in the sequence of this peptide are strongly modulated by their structural context. Nevertheless, mutations at different positions perturb in a correlated manner the free energies of aggregation as well as the lag times and growth rates. We show that these observations can be rationalized in terms of the intrinsic propensities for aggregation of the A\u03b2(1\u201340) sequence, thus suggesting that, in the case of this peptide, the determinants of the thermodynamics and of the nucleation and growth of the aggregates have a similar physicochemical basis.<\/jats:p>","DOI":"10.1110\/ps.062734207","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T10:43:51Z","timestamp":1180089831000},"page":"1214-1222","source":"Crossref","is-referenced-by-count":54,"title":["Similarities in the thermodynamics and kinetics of aggregation of disease\u2010related A\u03b2(1\u201340) peptides"],"prefix":"10.1002","volume":"16","author":[{"given":"Jessica","family":"Meinhardt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Gaetano","family":"Tartaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amol","family":"Pawar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Christopeit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hortschansky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volker","family":"Schroeckh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Dobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Vendruscolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"F\u00e4ndrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0501030"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300825200"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2000.3514"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/416507a"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.7.3590"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.7.1441"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb752"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01891"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.051470405"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2000.0758"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02261"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.06.043"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.03607204"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.11.009"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf573"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/35065514"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0303758100"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1012"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-0278(98)00002-9"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00159a011"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.66.1.385"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.041266605"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.051585905"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1139\/v91-240"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405933101"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(03)00927-6"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04533"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(96)80092-3"},{"key":"e_1_2_7_30_1","doi-asserted-by":"crossref","first-page":"27110","DOI":"10.1016\/S0021-9258(19)61486-9","article-title":"Substitutions at codon 22 of Alzheimer's A\u03b2 peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells","volume":"275","author":"Miravalle L.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00430-8"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn0901-887"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi050927h"},{"key":"e_1_2_7_34_1","volume-title":"Thermodynamics of the polymerisation of protein","author":"Oosawa F.","year":"1975"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560041120"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2005.04.016"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.6.1254"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.062116206"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.05.033"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.262663499"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02264"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03989"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.04663504"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0511295103"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104135200"},{"key":"e_1_2_7_46_1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1042\/bj3550869","article-title":"In vitro studies of amyloid \u03b2\u2010protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692 \u2192 Gly) Alzheimer's disease","volume":"35","author":"Walsh D.M.","year":"2001","journal-title":"Biochem. J."},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi9810757"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560041008"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.11211"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)09003-5"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00399-6"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)09015-1"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.041024904"}],"container-title":["Protein Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1110%2Fps.062734207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1110\/ps.062734207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T07:10:45Z","timestamp":1695971445000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1110\/ps.062734207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1110\/ps.062734207"],"URL":"https:\/\/doi.org\/10.1110\/ps.062734207","archive":["Portico"],"relation":{},"ISSN":["0961-8368","1469-896X"],"issn-type":[{"value":"0961-8368","type":"print"},{"value":"1469-896X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}