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Currently, nine genes have been identified as causative for <jats:styled-content style=\"fixed-case\">HPS<\/jats:styled-content> in humans. Hypopigmentation is the prominent feature of <jats:styled-content style=\"fixed-case\">HPS<\/jats:styled-content>, attributable to the disrupted biogenesis of melanosome, a member of the lysosome\u2010related organelle (<jats:styled-content style=\"fixed-case\">LRO<\/jats:styled-content>) family. Current understanding of the cargo transporting mechanisms into the melanosomes expands our knowledge of the pathogenesis of hypopigmentation in <jats:styled-content style=\"fixed-case\">HPS<\/jats:styled-content> patients.<\/jats:p>","DOI":"10.1111\/1346-8138.12025","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T07:04:41Z","timestamp":1368515081000},"page":"325-329","source":"Crossref","is-referenced-by-count":19,"title":["Hypopigmentation in <scp>H<\/scp>ermansky\u2013<scp>P<\/scp>udlak syndrome"],"prefix":"10.1111","volume":"40","author":[{"given":"Ai\u2010Hua","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing China"},{"name":"Department of Dermatology Beijing Tongren Affiliated Hospital of Capital Medical University Beijing 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