{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:54:40Z","timestamp":1759179280544},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,5]],"date-time":"2013-01-05T00:00:00Z","timestamp":1357344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"Abstract<\/jats:title>Acanthosis nigricans (AN<\/jats:styled-content>) usually correlates to insulin resistance (IR<\/jats:styled-content>) or obesity in obese populations, but adequate studies on the significance of AN<\/jats:styled-content> in people with normal body mass index (BMI<\/jats:styled-content>) have not been performed and discussed. Three hundred and thirty\u2010nine polycystic ovary syndrome (PCOS<\/jats:styled-content>) patients with normal BMI<\/jats:styled-content> (<23\u00a0kg\/m2<\/jats:sup>) were recruited. The anthropometric and biochemical parameters of these patients were measured. In these patients with normal BMI<\/jats:styled-content>, 33 (9.7%) women had AN<\/jats:styled-content>, and six (1.77%) women were diagnosed with metabolic syndrome. Most of the anthropometric and biochemical variables associated with metabolic status were more unfavorable in the AN\u2010positive group compared with the AN\u2010negative groups. The prevalence of central obesity, IR<\/jats:styled-content> and reduced high\u2010density lipoprotein cholesterol (HDL<\/jats:styled-content>\u2010C) level were also significantly higher in the AN\u2010positive group (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05). In multiple regression analysis, presence of AN was still significantly associated with IR<\/jats:styled-content> (odds ratio [OR<\/jats:styled-content>]\u00a0=\u00a02.952, 95% confidence intervals [CI<\/jats:styled-content>]\u00a0=\u00a01.367\u20136.376] and reduced HDL\u2010C<\/jats:styled-content> level (OR<\/jats:styled-content>\u00a0=\u00a02.668, 95% CI<\/jats:styled-content>\u00a0=\u00a01.160\u20136.135) after adjustments for age and BMI<\/jats:styled-content>. Sensitivity, specificity, and positive and negative predictive values for AN to detect IR<\/jats:styled-content> were 18.6%, 92.6%, 39.4% and 81.4%, respectively. In conclusion, presence of AN correlated with IR<\/jats:styled-content> and reduced HDL\u2010C<\/jats:styled-content> level in PCOS<\/jats:styled-content> women with normal BMI<\/jats:styled-content>. AN status had high specificity to detect IR<\/jats:styled-content>, but lack of sensitivity.<\/jats:p>","DOI":"10.1111\/1346-8138.12052","type":"journal-article","created":{"date-parts":[[2013,1,5]],"date-time":"2013-01-05T06:32:59Z","timestamp":1357367579000},"page":"188-192","source":"Crossref","is-referenced-by-count":11,"title":["Associations of acanthosis nigricans with metabolic abnormalities in polycystic ovary syndrome women with normal body mass index"],"prefix":"10.1111","volume":"40","author":[{"given":"Zhe","family":"Dong","sequence":"first","affiliation":[{"name":"Center of Assisted Reproductive Technology Guangzhou Women and Children's Medical Center Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongzi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sun 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