{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:53:43Z","timestamp":1771674823466,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Drinking water is an important nutrient for human health. The mineral ingredients included in drinking water may affect the physical condition of people. Various kinds of natural water are in circulation as bottled water in developed countries; however, its influence on clinical conditions of patients with certain diseases has not been fully evaluated. In this study, effects of the natural groundwater from Jeju Island on clinical symptoms and skin barrier function in atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) were evaluated. <jats:styled-content style=\"fixed-case\">NC<\/jats:styled-content>\/Tnd mice, a model for human <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>, with moderate to severe dermatitis were used. Mice were given different natural groundwater or tap water for 8\u00a0weeks from 4\u00a0weeks of age. Clinical skin severity scores were recorded every week. Scratching analysis and measurement of transepidermal water loss were performed every other week. The pathological condition of the dorsal skin was evaluated histologically. Real\u2010time polymerase chain reaction analysis was performed for cytokine expression in the affected skin. The epidermal hyperplasia and allergic inflammation were reduced in atopic mice supplied with Jeju groundwater when compared to those supplied with tap water or other kinds of natural groundwater. The increase in scratching behavior with the aggravation of clinical severity of dermatitis was favorably controlled. Moreover, transepidermal water loss that reflects skin barrier function was recovered. The early inflammation and hypersensitivity in the atopic skin was alleviated in mice supplied with Jeju groundwater, suggesting its profitable potential on the daily care of patients with skin troubles including <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.12055","type":"journal-article","created":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T14:42:52Z","timestamp":1357569772000},"page":"193-200","source":"Crossref","is-referenced-by-count":6,"title":["Daily intake of <scp>J<\/scp>eju groundwater improves the skin condition of the model mouse for human atopic dermatitis"],"prefix":"10.1111","volume":"40","author":[{"given":"Akane","family":"Tanaka","sequence":"first","affiliation":[{"name":"Laboratories of Comparative Animal Medicine Tokyo Japan"},{"name":"Laboratory of Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungsook","family":"Jung","sequence":"additional","affiliation":[{"name":"Laboratory of Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Veterinary Molecular Pathology and Therapeutics Division of Animal Life Science Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyosun","family":"Jang","sequence":"additional","affiliation":[{"name":"Laboratory of Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Kajiwara","sequence":"additional","affiliation":[{"name":"Laboratory of Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Amagai","sequence":"additional","affiliation":[{"name":"Laboratory of Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Oida","sequence":"additional","affiliation":[{"name":"Laboratory of Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginnae","family":"Ahn","sequence":"additional","affiliation":[{"name":"Laboratories of Comparative Animal Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keitaro","family":"Ohmori","sequence":"additional","affiliation":[{"name":"Laboratory of Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Tokyo Japan"},{"name":"Veterinary Molecular Pathology and Therapeutics Division of Animal Life Science Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010goo","family":"Kang","sequence":"additional","affiliation":[{"name":"Research and Development Department Jeju Special Self\u2010Governing Province Development Corporation Jeju Island Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Laboratory of Cooperative Major in Advanced Health Science Graduate School of Bio\u2010Applications and System Engineering Tokyo University of Agriculture and Technology Tokyo Japan"},{"name":"Veterinary Molecular Pathology and Therapeutics Division of Animal Life Science Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000182544.37724.b5"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1172\/JCI21060","article-title":"New insights into atopic dermatitis","volume":"13","author":"Leung DY","year":"2004","journal-title":"J Clin Invest"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2006.06.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2005.02.006"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051745"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.043"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.03.012"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.67.915"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.375"},{"key":"e_1_2_6_11_1","volume-title":"Spontaneous mouse model of atopic dermatitis in NC\/Nga mice","author":"Kawamoto K","year":"2004"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.106"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/intimm\/9.3.461","article-title":"Development of atopic dermatitis\u2010like skin lesion with IgE hyperproduction in NC\/NgaTnd mice","volume":"9","author":"Matsuda H","year":"1997","journal-title":"Int Immunol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.4049\/jimmunol.162.2.1056","article-title":"IgE hyperproduction through enhanced tyrosine phosphorylaion of Janus kinase 3 in NC\/NgaTnd mice, a model for human atopic dermatitis","volume":"162","author":"Matsumoto M","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.10.5955"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7613"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.03946.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1109\/TASE.2007.902868"},{"key":"e_1_2_6_19_1","article-title":"Real\u2010time scratching behavior quantification system for laboratory mice using high\u2010speed vision","author":"Nie Y","year":"2012","journal-title":"J Real\u2010Time Image Proc"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700603"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000110886"},{"key":"e_1_2_6_22_1","first-page":"136","article-title":"Prophylactic effect of oral administration of Lactobacillus johnsonii NCC533 (La1) during the weaning period on atopic dermatitis in NC\/NgaTnd mice","volume":"18","author":"Tanaka A","year":"2008","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555177913"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00895.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.11.001"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e3181dbf489"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02645.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004903"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00413.x"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12055","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T03:38:10Z","timestamp":1698637090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,7]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/1346-8138.12055"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12055","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,7]]}}}