{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T20:48:26Z","timestamp":1760820506558},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T00:00:00Z","timestamp":1358726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There are a limited number of reports indicating the role of human leukocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) class I alleles in pemphigus vulgaris. This study was designed to highlight the association of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> class I alleles with pemphigus vulgaris in Iran. Fifty patients with pemphigus vulgaris, diagnosed based on clinical, histological and direct immunofluorescence findings were enrolled into this study. The control group consisted of 50 healthy, age\u2010 and sex\u2010matched individuals. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> typing of class I (A, B and C alleles) was carried out using polymerase chain reaction based on the sequence\u2010specific primer method. This study showed the higher frequency of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*44:02 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.007), \u2010C*04:01 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), \u2010C*15:02 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and \u2010C*16:01 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.027) in the patient group, compared to the controls, while the frequency of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*06:02 (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and \u2010C*18:01 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.008) in the patients with pemphigus vulgaris was significantly lower than the controls. Regarding the linkage disequilibrium between <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> class I alleles, the <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A*03:01, \u2010B*51:01, \u2010C*16:02 haplotype (4% vs 0%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.04) is suggested to be a predisposing factor, whereas <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A*26:01, \u2010B*38, \u2010C*12:03 haplotype (0% vs 6%, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01) is suggested to be a protective factor. In conclusion, it is suggested that <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*44:02, \u2010C*04:01, \u2010C*15:02 alleles and HLA\u2010A*03:01, \u2010B*51:01, \u2010C*16:02 haplotype are susceptibility factors for development of pemphigus vulgaris in the Iranian population, while <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*06:02, \u2010C*18:01 alleles and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A*26:01, \u2010B*38, \u2010C*12:03 haplotype may be considered as protective alleles.<\/jats:p>","DOI":"10.1111\/1346-8138.12071","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T12:08:46Z","timestamp":1358770126000},"page":"244-248","source":"Crossref","is-referenced-by-count":21,"title":["Association of human leukocyte antigen class I antigens in Iranian patients with pemphigus 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Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hesam","family":"Toofan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Hooshang","family":"Ehsani","sequence":"additional","affiliation":[{"name":"Department of Dermatology Razi Hospital Tehran University of Medical Sciences Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Hamed","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Knowledge Utilization Research Center School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nima","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Molecular Immunology Research Center 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