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However, subsidiary subjects have arisen in the course of treatment which may directly impact the continued use of these drugs in a given case. In this article, we report two cases of psoriasis vulgaris refractory to treatment with both adalimumab and infliximab. We measured the serum drug concentration and absorbance value of antidrug antibodies using the sandwich enzyme\u2010linked immunoassay method. Antibodies to adalimumab and infliximab were detected in both patients. The low drug concentration and adverse clinical response observed corroborated these findings. Dosage and concomitant medication are considered to be important factors influencing the development of antibody formation. Therapeutic drug monitoring and measurement of antidrug antibodies will assist in maintaining a clinical response and in optimizing the response of patients being treated with biological therapies. The use of concomitant immunosuppressive medication should be considered for patients who will be treated with their second <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> inhibitor after having developed antidrug antibodies against their first <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> inhibitor.<\/jats:p>","DOI":"10.1111\/1346-8138.12093","type":"journal-article","created":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T22:48:02Z","timestamp":1361227682000},"page":"389-392","source":"Crossref","is-referenced-by-count":16,"title":["Anti\u2010adalimumab and anti\u2010infliximab antibodies developed in psoriasis vulgaris patients reduced the efficacy of biologics: Report of two cases"],"prefix":"10.1111","volume":"40","author":[{"given":"Yuka","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoji","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukari","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,18]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0183-7"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67566-6"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.406"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.347"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.057406"},{"key":"e_1_2_4_7_1","unstructured":"Data from an Application Packet for Pharmaceuticals and Medical Device Agency Abbott Japan Co. 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