{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:10:13Z","timestamp":1760044213675},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:00:00Z","timestamp":1368489600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Abstract<\/jats:title>A 38\u2010year\u2010old female patient suffered from alopecia areata totalis followed by human T\u2010cell lymphotropic virus\u20101\u2010associated myelopathy (HAM<\/jats:styled-content>). These two diseases have recently been considered to be related to cell\u2010mediated autoimmune reactions. Immunohistochemistry revealed accumulation of CXCR<\/jats:styled-content>3+<\/jats:sup> CD<\/jats:styled-content>8+<\/jats:sup> T cells around hair bulbs in alopecic lesions. Furthermore, flow cytometric analysis showed the elevated frequency of CD<\/jats:styled-content>8+<\/jats:sup> human leukocyte antigen DR<\/jats:styled-content>+<\/jats:sup>\u2010activated T cells at the initial time and declined at the hair regrowth phase with HAM<\/jats:styled-content>. CD<\/jats:styled-content>4+<\/jats:sup> CD<\/jats:styled-content>25+<\/jats:sup> adult T\u2010cell leukemia\/lymphoma cells were elevated at hair loss phase and decreased after improvement of hair loss. These results suggest that autoreactive and cytotoxic CD<\/jats:styled-content>8+<\/jats:sup> T cells induce not only alopecia areata but also HAM<\/jats:styled-content> in ATL<\/jats:styled-content> patients. This case highlights that the autoimmune reactions may play an important role in the pathogenesis of alopecia areata and HAM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.12128","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T07:04:41Z","timestamp":1368515081000},"page":"399-401","source":"Crossref","is-referenced-by-count":6,"title":["Alopecia areata possibly induced by autoimmune reaction in a patient with human T\u2010cell lymphotropic virus\u20101\u2010associated myelopathy"],"prefix":"10.1111","volume":"40","author":[{"given":"Taisuke","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Shimada","sequence":"additional","affiliation":[{"name":"Shimada Dermatoclinic Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuyoshi","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fujinomiya City General Hospital Fujinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Tokura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,14]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1103442"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2012.12.003"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2002.01077.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S146239940601101X"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)70152-6"},{"key":"e_1_2_4_7_1","first-page":"541","article-title":"Is alopecia areata an autoimmune\u2010response against melanogenesis\u2010related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb?","volume":"66","author":"Paus R","year":"1993","journal-title":"Yale J Biol Med"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01583.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100657"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780390821"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21985"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91362-6"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)92744-4"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90038-X"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90630-0"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12128","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T14:55:22Z","timestamp":1694444122000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["10.1111\/1346-8138.12128"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12128","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}