{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:51:41Z","timestamp":1761706301136},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T00:00:00Z","timestamp":1367020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>g dressings, a combination of technology lipido\u2010colloid and silver salts, are used to promote healing in wounds with risks or signs of local infection, thanks to the antimicrobial properties of the silver salts. Nanocrystalline silver dressings containing nanocrystalline silver, also used to improve wound healing, present both antimicrobial and anti\u2010inflammatory effects. The aim of this study was to investigate the anti\u2010inflammatory effects of <jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>g dressings in a model of chronic skin inflammation induced by repeated application of 12\u2010<jats:italic>O<\/jats:italic>\u2010tetradecanoylphorbol\u201013\u2010acetate to the skin of hairless mice, in comparison with <jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content> dressing, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ilcryst nanocrystalline dressing, desonide cream 0.05%, a corticoid cream used as positive control, and gauze. Daily treatments of the mice began 7\u00a0days after the start of induction of chronic skin inflammation and lasted for 7\u00a0days. A macroscopic score was performed daily during the treatment period until the mice killing on day 15 and skin samples were taken for histopathological analysis. <jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>g reduced significantly the macroscopic score of chronic skin inflammation from day 10 in comparison with gauze and <jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content> dressing, similarly to <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ilcryst nanocrystalline dressing and desonide cream, which presented the best anti\u2010inflammatory effects. No significant differences were observed between <jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content> dressing and gauze. <jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>g reduced significantly the microscopic score of chronic skin inflammation in comparison with <jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content> dressing and gauze, similarly to <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ilcryst nanocrystalline dressing but significantly less than desonide cream. These results demonstrate that <jats:styled-content style=\"fixed-case\">TLC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>g dressings present significant anti\u2010inflammatory effects on chronic skin inflammation. They can improve wound healing, due to both the antimicrobial and anti\u2010inflammatory properties.<\/jats:p>","DOI":"10.1111\/1346-8138.12149","type":"journal-article","created":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T16:56:56Z","timestamp":1367081816000},"page":"463-470","source":"Crossref","is-referenced-by-count":8,"title":["Effects of <scp>TLC<\/scp>\u2010<scp>A<\/scp>g dressings on skin inflammation"],"prefix":"10.1111","volume":"40","author":[{"given":"Jean\u2010Fran\u00e7ois","family":"Bisson","sequence":"first","affiliation":[{"name":"Department of Cancerology, Human Pathologies and Toxicology ETAP Research Center Vand\u0153uvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Hidalgo\u2010Lucas","sequence":"additional","affiliation":[{"name":"Department of Cancerology, Human Pathologies and Toxicology ETAP Research Center Vand\u0153uvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marielle","family":"Bouschbacher","sequence":"additional","affiliation":[{"name":"Research Department Laboratoires URGO Chen\u00f4ve France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laetitia","family":"Thomassin","sequence":"additional","affiliation":[{"name":"Urgo Medical Laboratoires URGO Chen\u00f4ve France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2011.00881.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2012.21.2.96"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6468(08)70024-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01515.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06575.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2010.00579.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2008.04.006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.06.016"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2004.tb00657.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000210960"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.29.1046"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01965041"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.11.045"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.12968\/jowc.2005.14.5.26775"},{"key":"e_1_2_7_16_1","unstructured":"Directive 2010\/63\/EU of the European Parliament and of the Council of 22 September 2010 on the Protection of Animals used for Scientific Purposes. 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