{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:00:28Z","timestamp":1773270028279,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T00:00:00Z","timestamp":1367020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plasma cell cheilitis is a chronic inflammatory disease that presents with erythema, erosions, ulcers and occasional nodules within the mucosa, including the lips. It is histopathologically characterized by dense plasma cell infiltration in the lamina propria of the mucous membranes. Several treatments for plasma cell cheilitis have been reported, including topical steroids, topical antibiotics or topical tacrolimus. However, 308\u2010nm monochromatic excimer light (<jats:styled-content style=\"fixed-case\">MEL<\/jats:styled-content>) has never been reported as a treatment option, while it was reported to be very effective in treating erosive oral lichen planus. We report a 62\u2010year\u2010old man who had chronic plasma cell cheilitis on the lower lip, which was refractory to topical and systemic corticosteroid. The lesion and severe pain were significantly improved by the treatment with nine sessions of 308\u2010nm <jats:styled-content style=\"fixed-case\">MEL<\/jats:styled-content> twice per week with a total dose of 1120\u00a0mJ\/cm<jats:sup>2<\/jats:sup>. However, the lesion gradually worsened after treatment frequency was reduced to once per month. Subsequent tacrolimus 0.03% ointment cleared the lesion completely in a month and no recurrence was observed a year later. Refractory plasma cell cheilitis and concomitant severe pain quickly responded to 308\u2010nm <jats:styled-content style=\"fixed-case\">MEL<\/jats:styled-content> when administrated twice per week. Because the long interval between each <jats:styled-content style=\"fixed-case\">MEL<\/jats:styled-content> treatment seemed ineffective to improve the lesion, appropriate frequency and adequate total dose of <jats:styled-content style=\"fixed-case\">MEL<\/jats:styled-content> treatment may be necessary for a successful treatment.<\/jats:p>","DOI":"10.1111\/1346-8138.12152","type":"journal-article","created":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T16:57:01Z","timestamp":1367081821000},"page":"471-474","source":"Crossref","is-referenced-by-count":5,"title":["Successful treatment with 308\u2010nm monochromatic excimer light and subsequent tacrolimus 0.03% ointment in refractory plasma cell cheilitis"],"prefix":"10.1111","volume":"40","author":[{"given":"Kazuhiro","family":"Yoshimura","sequence":"first","affiliation":[{"name":"Nakano Medical Clinic Miyazaki Japan"},{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Nakano","sequence":"additional","affiliation":[{"name":"Nakano Medical Clinic Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chika","family":"Ohata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and Kurume University Institute of Cutaneous Cell Biology Kurume Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine, and 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