{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T21:32:16Z","timestamp":1768771936212,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T00:00:00Z","timestamp":1368144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recurrent aphthous stomatitis (<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>) has a multifactorial etiopathogenesis, an interaction between predisposing factors and\/or systemic conditions and immunological components in genetically predisposed subjects. The Mediterranean fever (<jats:styled-content style=\"fixed-case\"><jats:italic>MEFV<\/jats:italic><\/jats:styled-content>) gene has already been identified as being responsible for familial Mediterranean fever. Because the association between<jats:styled-content style=\"fixed-case\"><jats:italic>MEFV<\/jats:italic><\/jats:styled-content>gene mutations and Beh\u00e7et's disease has been reported before in several studies, we considered that the role of<jats:styled-content style=\"fixed-case\"><jats:italic>MEFV<\/jats:italic><\/jats:styled-content>gene mutations should be studied in patients with<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>, because of the clinical similarities of both diseases. The aim of this study was to explore the frequency and clinical significance of<jats:styled-content style=\"fixed-case\"><jats:italic>MEFV<\/jats:italic><\/jats:styled-content>gene mutations in a cohort of Turkish patients with<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>. The study population comprised 100 unrelated patients with a clinical diagnosis of<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>and 156 healthy controls. Genomic<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>was isolated and genotyped using polymerase chain reaction and restriction fragment length polymorphism for the four<jats:styled-content style=\"fixed-case\"><jats:italic>MEFV<\/jats:italic><\/jats:styled-content>gene mutations (M694V, M680I, V726A and E148Q). There were statistically significant differences of the<jats:styled-content style=\"fixed-case\"><jats:italic>MEFV<\/jats:italic><\/jats:styled-content>gene mutation carrier rates and allele frequencies between RAS patients and healthy controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.042, odds ratio [OR]\u00a0=\u00a01.9, 95% confidence interval [CI]\u00a0=\u00a01.01\u20133.41; and<jats:italic>P<\/jats:italic>\u00a0=\u00a00.039, OR\u00a0=\u00a01.8, 95% CI\u00a0=\u00a01.02\u20133.14, respectively). Even if it is not statistically significant, the E148Q allele frequency was higher in patients with<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>than the control group. A statistically significant increased prevalence of<jats:styled-content style=\"fixed-case\"><jats:italic>MEFV<\/jats:italic><\/jats:styled-content>variants in<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>patients was found. This is the first study to report that missense mutations of<jats:styled-content style=\"fixed-case\"><jats:italic>MEFV<\/jats:italic><\/jats:styled-content>is associated with<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>in the Turkish population.<\/jats:p>","DOI":"10.1111\/1346-8138.12159","type":"journal-article","created":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T18:23:06Z","timestamp":1368210186000},"page":"516-521","source":"Crossref","is-referenced-by-count":7,"title":["Association between<scp><i>MEFV<\/i><\/scp>gene mutations and recurrent aphthous stomatitis in a cohort of Turkish patients"],"prefix":"10.1111","volume":"40","author":[{"given":"G\u00f6knur","family":"Kalkan","sequence":"first","affiliation":[{"name":"Department of Dermatovenerology Faculty of Medicine Gaziosmanpasa University Tokat 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