{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:27:47Z","timestamp":1767839267214,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,19]],"date-time":"2013-05-19T00:00:00Z","timestamp":1368921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>11<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> is a <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ruppel\u2010like <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>2<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>2\u2010type zinc finger transcription factor, which has been associated with several human malignancies. Recent evidence showed that overexpressed <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>11<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> conferred chemoresistance to malignant <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells and that inhibiting <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>11<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> led to increased apoptosis, suggesting its potential pathogenic relevance in cutaneous <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell lymphomas (<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>), which were characterized by the resistance to chemotherapy\u2010induced apoptosis. To investigate the expression pattern of <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>11<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> in different stages of mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>), quantitative reverse transcription polymerase chain reaction and immunohistochemistry were performed to compare the m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> and protein expression among different stages of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> and benign inflammatory dermatoses (<jats:styled-content style=\"fixed-case\">BID<\/jats:styled-content>), respectively. <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>11<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> demonstrated significant upregulation in all stages of MF, compared with <jats:styled-content style=\"fixed-case\">BID<\/jats:styled-content>, in both m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression level and protein level. In addition, <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>11<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> expression increased with advancing lesion tumor stage and overall disease stage. Further, to evaluate the dynamic expression of <jats:styled-content style=\"fixed-case\"><jats:italic>BCL11B<\/jats:italic><\/jats:styled-content> under <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\u2010directed treatment, <jats:styled-content style=\"fixed-case\"><jats:italic>BCL11B<\/jats:italic><\/jats:styled-content> expression and cell apoptosis were evaluated after interferon (IFN)\u2010\u03b1\u20102b and methotrexate treatment on <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content> cell line <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ut78 cells. <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1\u20102b, but not methotrexate, induced <jats:styled-content style=\"fixed-case\"><jats:italic>BCL11B<\/jats:italic><\/jats:styled-content> inhibition and cell apoptosis, suggesting that <jats:styled-content style=\"fixed-case\">BCL11B<\/jats:styled-content> may play important roles in the anti\u2010<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content> effect of <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b1\u20102b. In conclusion, our study demonstrated the overexpression of BCL11B in MF lesions and its potential relevance to disease progression. In addition, we provided evidence for <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>11<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> inhibitory approaches as a potential treatment to target chemoresistant tumor cells in advanced <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.12160","type":"journal-article","created":{"date-parts":[[2013,5,19]],"date-time":"2013-05-19T17:45:04Z","timestamp":1368985504000},"page":"596-605","source":"Crossref","is-referenced-by-count":15,"title":["Aberrant expression of <scp>BCL<\/scp>11<scp>B<\/scp> in mycosis fungoides and its potential role in interferon\u2010induced apoptosis"],"prefix":"10.1111","volume":"40","author":[{"given":"Xiaoguang","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venerology Peking University First Hospital Beijing 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