{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T15:32:37Z","timestamp":1767713557162},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T00:00:00Z","timestamp":1370217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This multicenter, randomized parallel group study investigated the efficacy and tolerability of adapalene 0.1% gel plus nadifloxacin 1% cream (combination therapy) compared with adapalene gel (monotherapy) during 12\u2010week treatment of acne vulgaris. A total of 184 <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese patients aged above 12\u00a0years with moderate to severe acne as indicated by the <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese severity grading criteria were randomized to combination therapy (<jats:italic>n\u00a0<\/jats:italic>=\u00a084) and monotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a0100) groups, both having comparable demographic and baseline characteristics. Adapalene was applied only to inflammatory acne lesions in order to minimize skin irritation and ensure the treatment results. Efficacy and safety evaluations, treatment compliance and satisfaction with drug application were periodically monitored. The combination therapy provided a significantly greater efficacy than adapalene in decrement of inflammatory papulopustular lesions at 4\u00a0weeks and thereafter (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.0056). The overall judgment of the therapeutic efficacy by the physician at the end of study revealed a significant difference (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02496) between the groups in favor of combination therapy. Dryness was reported in a greater proportion of patients undergoing monotherapy than combination therapy at weeks 2 and 4 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04652). The patient self\u2010assessment in satisfaction with the drug application at the end of study revealed a significant difference (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.00268) between the groups in favor of combination therapy. Among 76 strains of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ropionibacterium acnes<\/jats:italic> isolated from 87 patients, no strain was resistant to nadifloxacin. Thus, the simultaneous use of adapalene and nadifloxacin may provide an additive and complementary effect, resulting in clinical superiority and greater patient adherence compared to adapalene monotherapy.<\/jats:p>","DOI":"10.1111\/1346-8138.12189","type":"journal-article","created":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T11:44:48Z","timestamp":1370259888000},"page":"620-625","source":"Crossref","is-referenced-by-count":12,"title":["Clinical and bacteriological evaluation of adapalene 0.1% gel plus nadifloxacin 1% cream versus adapalene 0.1% gel in patients with acne vulgaris"],"prefix":"10.1111","volume":"40","author":[{"given":"Masahiro","family":"Takigawa","sequence":"first","affiliation":[{"name":"Hamamatsu University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Tokura","sequence":"additional","affiliation":[{"name":"Department of Dermatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Yamanashi Yamanashi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fukumi","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Wakayama Medical University Wakayama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihisa","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Microbiology School of Pharmacy Tokyo University of Pharmacy and Life Sciences Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisuke","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Dermatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Acne Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.02.018"},{"key":"e_1_2_6_4_1","first-page":"1","article-title":"Acne in Adolescents: quality of life, self\u2010esteem, mood, and psychological disorders","volume":"17","author":"Dunn LK","year":"2012","journal-title":"Dermatol Online J"},{"key":"e_1_2_6_5_1","first-page":"227","article-title":"What's new in antibiotics in the management of acne?","volume":"147","author":"Narahari S","year":"2012","journal-title":"G Ital Dermatol Venereol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2011.09.001"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/11208170-000000000-00000"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2008.06.005"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.01.019"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01450.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/11597880-000000000-00000"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2011.07.002"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)01152-6"},{"key":"e_1_2_6_14_1","first-page":"1893","article-title":"Guideline for the treatment of acne vulgaris","volume":"118","author":"Hayashi N","year":"2008","journal-title":"J Jap Assoc Dermatol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.7.14.1957"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01280.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2007.00403.x-i1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05067.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2008.00081.x"},{"key":"e_1_2_6_20_1","unstructured":"DavidW HechtDW CitronDMet\u00a0al.Methods of Antimicrobial Susceptibility Testing of Anaerobic Bacteria; Approved Standard Eighth Edition M11\u2010A8.2012;32:1\u201338."},{"key":"e_1_2_6_21_1","first-page":"79","article-title":"Retinoid plus antimicrobial combination treatments for acne","volume":"4","author":"Feneran AN","year":"2011","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04214.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2011.553192"},{"key":"e_1_2_6_24_1","first-page":"48","article-title":"Clinical and bacteriological evaluation of nadifloxacin 1% cream in patients with acne vulgaris: a double\u2010blind, phase III comparison study versus erythromycin 2% cream","volume":"16","author":"Plewig G","year":"2006","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.111340"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.3.337"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332847"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12189","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:27:24Z","timestamp":1696519644000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,3]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/1346-8138.12189"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12189","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"type":"print","value":"0385-2407"},{"type":"electronic","value":"1346-8138"}],"subject":[],"published":{"date-parts":[[2013,6,3]]}}}