{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T16:43:05Z","timestamp":1732034585050},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T00:00:00Z","timestamp":1373328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tenascins are a family of large multimetric extracellular matrix (<jats:styled-content style=\"fixed-case\">ECM<\/jats:styled-content>) proteins. Among them, large molecular weight variant tenascin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> is known to be specifically expressed in pathological conditions. However, no link between tenascin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> and collagen diseases has been established. The aim of our study was to determine the serum tenascin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> levels in patients with various collagen diseases, and to evaluate the possibility that serum levels of tenascin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> can be a useful marker for collagen diseases, correlating with the pathogenesis. Serum tenascin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> levels of 33 patients with scleroderma (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c), 10 patients with scleroderma spectrum disorder (<jats:styled-content style=\"fixed-case\">SSD<\/jats:styled-content>), 15 patients with localized scleroderma (<jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c), 12 patients with dermatomyositis (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>), 10 patients with systemic lupus erythematosus (<jats:styled-content style=\"fixed-case\">SLE<\/jats:styled-content>) and 15 healthy controls were measured with specific enzyme\u2010linked immunosorbent assays. Serum tenascin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> levels were significantly elevated in patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c, <jats:styled-content style=\"fixed-case\">SSD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>c than in healthy controls. Significantly higher total skin thickness score or higher incidence of pitting scars\/ulcers and diffuse pigmentation were observed in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with elevated tenascin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> levels than in those with normal levels. Our study suggests that serum tenascin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> levels are increased in fibrotic conditions, and that tenascin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> contributes to the pathogenesis of vascular damage as well as fibrosis in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients. Clarifying the role of tenascin\u2010<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> in the pathogenesis of collagen diseases may lead to a new therapeutic approach.<\/jats:p>","DOI":"10.1111\/1346-8138.12218","type":"journal-article","created":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T07:17:09Z","timestamp":1373354229000},"page":"715-719","source":"Crossref","is-referenced-by-count":17,"title":["Serum levels of tenascin\u2010<scp>C<\/scp> in collagen diseases"],"prefix":"10.1111","volume":"40","author":[{"given":"Kuniko","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Jinnin","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Plastic Surgery Faculty of Life Sciences Kumamoto University Kumamoto 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