{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:59:38Z","timestamp":1781013578220,"version":"3.54.1"},"reference-count":14,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Morphea is a type of localized scleroderma. It is a skin disease involving the development of fibrosis in the dermis and subcutaneous fat tissue beneath without a visceral lesion, and the cause is still unclear. An involvement of epithelial\u2013mesenchymal transition (<jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>) has been reported as a cause of tissue fibrosis, but this was mostly observed in pulmonary and hepatic fibrosis, and the involvement of <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content> in a skin disease, morphea, has not been studied . Thus, we analyzed the involvement of <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content> in skin fibrosis in morphea patients using pathological techniques. Skin lesions of six morphea patients were analyzed (five female and one male patient). As a control, non\u2010light\u2010exposed skin lesions of 11 healthy females were analyzed. Concretely, tissue samples were prepared from these subjects and subjected to immunostaining of transforming growth factor (<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>)\u2010\u03b21, \u03b1\u2010smooth muscle actin (\u03b1\u2010<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>) and fibronectin, which have been reported to be associated with fibrosis, and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>nail1 and <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\u2010cadherin, which are considered to be involved in <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>, and expressions of these were analyzed. In morphea patients, dermal expression of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b21, \u03b1\u2010<jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content> and fibronectin, which are involved in fibrosis, was enhanced, and, at the same time, enhanced expression of <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>nail1 and reduced expression of <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>\u2010cadherin, which are involved in <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content>, were observed in the dermal eccrine glands. These findings suggested the progression of <jats:styled-content style=\"fixed-case\">EMT<\/jats:styled-content> in the dermal eccrine glands in morphea.<\/jats:p>","DOI":"10.1111\/1346-8138.12235","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T05:52:42Z","timestamp":1373953962000},"page":"720-725","source":"Crossref","is-referenced-by-count":15,"title":["Epithelial\u2013mesenchymal transition of the eccrine glands is involved in skin fibrosis in morphea"],"prefix":"10.1111","volume":"40","author":[{"given":"Masayuki","family":"Takahashi","sequence":"first","affiliation":[{"name":"Departments of Dermatology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohiko","family":"Akamatsu","sequence":"additional","affiliation":[{"name":"Departments of Applied Cell and Regenerative Medicine Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Yagami","sequence":"additional","affiliation":[{"name":"Departments of Dermatology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Departments of Dermatology Fujita Health University School of Medicine Toyoake Japan"},{"name":"Departments of Research Laboratories Nippon Menard Cosmetic Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiroh","family":"Ohgo","sequence":"additional","affiliation":[{"name":"Departments of Research Laboratories Nippon Menard Cosmetic Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Abe","sequence":"additional","affiliation":[{"name":"Departments of Dermatology Fujita Health University School of Medicine Toyoake 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