{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:05:53Z","timestamp":1760346353742},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T00:00:00Z","timestamp":1375747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The T\u2010helper (Th)17 cell plays a crucial role in the pathogenesis of psoriasis, and several biological therapies have shown to be highly efficient in the treatment. However, some patients respond poorly to these therapies and may even develop paradoxical adverse effects. To evaluate the significance of serum immunological factors or circulating competent cells for biomarkers or predictors to biological therapies, we retrospectively analyzed 28 patients with psoriasis (19 psoriasis vulgaris, three pustular psoriasis and six psoriasis arthropathica). The numbers of patients treated with each agents were 16 for ustekinumab, six for adalimumab and six for infliximab. Patients were classified into three types according to the responsiveness: 13 patients were high\u2010responders showing a 75% or more reduction of Psoriasis Area and Severity Index (<jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>); 10 patients were moderate\u2010responders showing <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> reduction of less than 75%; and five patients were non\u2010responders showing <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content> elevation. During the treatments, serum levels of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201022 and vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>) were monitored. At baseline, serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 levels were significantly higher in the psoriatic patients than the normal controls. Both serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 and <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> levels significantly correlated with <jats:styled-content style=\"fixed-case\">PASI<\/jats:styled-content>. After the treatment, the high\u2010responders showed significant decreases in serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 and <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>. On the other hand, serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 levels in the non\u2010responders were elevated. However, the baseline levels of serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 and <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> were not significantly different between the three groups. These results suggest that serum <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201022 and <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> levels serve as sensitive biomarkers but not as predictors of therapeutic response to biologics in patients with psoriasis.<\/jats:p>","DOI":"10.1111\/1346-8138.12248","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T05:39:27Z","timestamp":1375767567000},"page":"805-812","source":"Crossref","is-referenced-by-count":38,"title":["Serum interleukin\u201022 and vascular endothelial growth factor serve as sensitive biomarkers but not as predictors of therapeutic response to biologics in patients with psoriasis"],"prefix":"10.1111","volume":"40","author":[{"given":"Takatoshi","family":"Shimauchi","sequence":"first","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu 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