{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:55:51Z","timestamp":1780066551210,"version":"3.54.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T00:00:00Z","timestamp":1377216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tumor necrosis factor (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>)\u2010like weak inducer of apoptosis (<jats:styled-content style=\"fixed-case\">TWEAK<\/jats:styled-content>), a member of the <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> family, has been implicated as a pro\u2010inflammatory cytokine in many types of autoimmune and infectious diseases. However, information about <jats:styled-content style=\"fixed-case\">TWEAK<\/jats:styled-content> in dermatological diseases is limited. To date, no studies have investigated the roles of <jats:styled-content style=\"fixed-case\">TWEAK<\/jats:styled-content> in patients with urticarial vasculitis (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>). This study aimed to assess serum <jats:styled-content style=\"fixed-case\">TWEAK<\/jats:styled-content> levels, together with <jats:styled-content style=\"fixed-case\">TWEAK<\/jats:styled-content> and fibroblast growth factor\u2010inducible 14 (<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>n14) expressions of skin lesions in patients with <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>. Serum <jats:styled-content style=\"fixed-case\">TWEAK<\/jats:styled-content> levels in patients with <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>, together with patients with cutaneous leukocytoclastic angiitis (<jats:styled-content style=\"fixed-case\">CLA<\/jats:styled-content>) and healthy controls were detected by enzyme\u2010linked immunosorbent assay; <jats:styled-content style=\"fixed-case\">TWEAK<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>n14 expressions of skin lesions were analyzed by immunohistochemistry. Results showed that <jats:styled-content style=\"fixed-case\">TWEAK<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>n14 were abundantly expressed in the dermal vessel wall of lesional skin in patients with <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> but not healthy controls. Serum <jats:styled-content style=\"fixed-case\">TWEAK<\/jats:styled-content> levels in the acute stage in patients with <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> were significantly higher than those in the convalescent stage and healthy controls. Serum <jats:styled-content style=\"fixed-case\">TWEAK<\/jats:styled-content> levels were elevated significantly in patients with <jats:styled-content style=\"fixed-case\">CLA<\/jats:styled-content> compared with those in healthy controls. Our previous study indicated that <jats:styled-content style=\"fixed-case\">TWEAK<\/jats:styled-content> may be an important mediator for the development of vascular inflammation in skin. In addition, we also found that <jats:styled-content style=\"fixed-case\">TWEAK<\/jats:styled-content> blockade substantially reduced vascular damage and perivascular leukocyte infiltrates in lipopolysaccharide\u2010induced cutaneous vasculitis. Our study shows that <jats:styled-content style=\"fixed-case\">TWEAK<\/jats:styled-content> may be associated with the pathogenesis of <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>; it is therefore suggested that <jats:styled-content style=\"fixed-case\">TWEAK<\/jats:styled-content> may be a potential therapeutic target for <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> and other types of cutaneous vasculitis.<\/jats:p>","DOI":"10.1111\/1346-8138.12251","type":"journal-article","created":{"date-parts":[[2013,8,23]],"date-time":"2013-08-23T05:19:16Z","timestamp":1377235156000},"page":"891-895","source":"Crossref","is-referenced-by-count":15,"title":["Tumor necrosis factor\u2010like weak inducer of apoptosis and its receptor fibroblast growth factor\u2010inducible 14 are expressed in urticarial vasculitis"],"prefix":"10.1111","volume":"40","author":[{"given":"Mengmeng","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatovenereology West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaipei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology West China Hospital of Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-007-0050-x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200001000-00005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:23:2:201"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02847.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.51.32401"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70204-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00232-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64996-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(02)00368-5"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02670-0"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115.2.267"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.9.1373"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.10.6020"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.1.341"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401107"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.2.734"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1879"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.68.396"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22419.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.036"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2741\/2341"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2816"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081310"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740801898608"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02760409"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04442.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.10.962"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000246646.45651.a2"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2009.06.010"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2008.12.001"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.11.7949"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2488"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2010.512403"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000062883.93715.37"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056830"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.12251","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.12251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T17:24:58Z","timestamp":1696267498000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.12251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,23]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/1346-8138.12251"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.12251","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,23]]}}}